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Table 3 Association between BMI (per 1 standard deviation increment1) and the risk of obesity-related cancer by ascertainment of cardiometabolic diseases, in EPIC and UKB cohorts

From: Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies

 

EPIC

UKB

N at risk / N cases

HR (95% CI)

p2

p3

p4

N at risk / N cases

HR (95% CI)

p2

p3

p4

Obesity-related cancers

 Base model5

233,249 / 7,892

1.10 (1.08; 1.12)

 < 0.001

  

344,094 / 12,526

1.16 (1.14; 1.18)

 < 0.001

  

 Overall adj. model6

233,249 / 7,892

1.09 (1.07; 1.11)

 < 0.001

  

344,094 / 12,526

1.14 (1.12; 1.16)

 < 0.001

  

 Without CMD7,8

233,249 / 7,382

1.09 (1.07; 1.11)

 < 0.001

 

0.95

344,094 / 1,354

1.14 (1.12; 1.16)

 < 0.001

 

0.52

 T2D7

9,961 / 311

1.11 (1.03; 1.19)

0.005

0.75

 

14,149 / 291

1.12 (1.03; 1.22)

 < 0.001

0.68

 

 CVD7

8,746 / 168

1.11 (0.98; 1.24)

0.09

0.84

 

29,778 / 813

1.19 (1.12; 1.25)

 < 0.001

0.17

 

 T2D-CVD7

940 / 31

1.03 (0.79; 1.35)

0.81

0.67

 

2,464 / 68

1.11 (0.94;1.31)

0.23

0.74

 
  1. Abbreviations: SD standard deviation, BMI body mass index, HR hazard ratio, 95%CI 95% confidence intervals, T2D type 2 diabetes, CVD cardiovascular diseases, CMD cardiometabolic diseases, EPIC European Prospective Investigation into Cancer and nutrition, UKB UK Biobank
  2. 1Standard deviation (SD) of BMI in EPIC = 4.18 kg/m2; Standard deviation (SD) of BMI in UKB = 4.60 kg/m2
  3. P-values: 2 p-values for association of local association tests;3 p-values for the individual interaction term; 4 p-value from likelihood ratio test comparing models with and without an interaction term
  4. 5Base model adjusted for educational level, alcohol consumption, smoking status, height, physical activity, healthy diet score, menopausal status for women, use of HRT for women, and stratified by centre of recruitment, age (5-year categories), and sex
  5. 6Overall adjusted model (further adjusted for CMD, modelled as a time-varying variable, and the duration of these comorbidities)
  6. 7Overall adjusted model with an interaction term between BMI and CMD (modelled as a time-varying variable)
  7. 8Without CVD and T2D
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BMC Medicine

ISSN: 1741-7015

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