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Fig. 1 | BMC Medicine

Fig. 1

From: Associations between maternal metabolic conditions and neurodevelopmental conditions in offspring: the mediating effects of obstetric and neonatal complications

Fig. 1

Study sample derivation. Superscript lowercase letter a “a” indicates the following: children born before 1987 were excluded from the study population because data on gestational diabetes mellitus (GDM) diagnoses were only available from 1987 onwards. Superscript lowercase letter b “b” indicates the following: exclusions were made stepwise, as illustrated. Superscript lowercase letter c “c” indicates the following: individuals lacking information from the Medical Birth Register (MBR) were excluded. Superscript lowercase letter d “d” indicates the following: children with co-morbid congenital malformations (or inborn errors of metabolism) and neurodevelopmental disorders (NDCs) were excluded, as these NDCs may be attributable to the congenital condition. Superscript lowercase letter e “e” indicates the following: children of mothers diagnosed with GDM were excluded from the PGDM cohort. Superscript lowercase letter f “f” indicates the following: children of mothers diagnosed with PGDM were excluded from the GDM cohort. Superscript lowercase letter g “g” indicates the following: children of mothers who were underweight or lacked BMI information were excluded from the adiposity cohort

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