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Table 1 Characteristics of the study sample over exposures

From: Associations between maternal metabolic conditions and neurodevelopmental conditions in offspring: the mediating effects of obstetric and neonatal complications

 

No diabetes

PGDM

GDM

Normal weight

Adiposity

(n=2309663)

(n=22127)

(n=21179)

(n=1156856)

(n=554010)

Characteristics

 Any NDCs

132502 (5.7%)

1814 (8.2%)

1516 (7.2%)

58241 (5.0%)

37690 (6.8%)

 Autism

44469 (1.9%)

608 (2.7%)

577 (2.7%)

19765 (1.7%)

12777 (2.3%)

 ADHD

99634 (4.3%)

1318 (6.0%)

1034 (4.9%)

44014 (3.8%)

28731 (5.2%)

 ID

20092 (0.9%)

366 (1.7%)

306 (1.4%)

7952 (0.7%)

6029 (1.1%)

Child’s sex

 Male

1185538 (51.3%)

11307 (51.1%)

11026 (52.1%)

593437 (51.3%)

284691 (51.4%)

 Female

1124125 (48.7%)

10820 (48.9%)

10153 (47.9%)

563419 (48.7%)

269319 (48.6%)

Birthyear

 1987-1992

647353 (28.0%)

6073 (27.4%)

5251 (24.8%)

228965 (19.8%)

56782 (10.2%)

 1993-1998

553617 (24.0%)

5124 (23.2%)

5070 (23.9%)

312194 (27.0%)

138007 (24.9%)

 1999-2004

515651 (22.3%)

5027 (22.7%)

4793 (22.6%)

281640 (24.3%)

159325 (28.8%)

 2005-2010

593042 (25.7%)

5903 (26.7%)

6065 (28.6%)

334057 (28.9%)

199896 (36.1%)

Maternal age, mean (SD)

29.2 (5.1)

29.9 (5.4)

31.7 (5.4)

29.3 (5.0)

29.9 (5.2)

Maternal birth country

 Nordic

1992882 (86.3%)

18736 (84.7%)

15142 (71.5%)

1007793 (87.1%)

466840 (84.3%)

 Europe

97710 (4.2%)

545 (2.5%)

1125 (5.3%)

50909 (4.4%)

22642 (4.1%)

 Africa

41345 (1.8%)

815 (3.7%)

1047 (4.9%)

15989 (1.4%)

15099 (2.7%)

 Asia

148144 (6.4%)

1803 (8.1%)

3432 (16.2%)

69126 (6.0%)

41116 (7.4%)

 Other

29582 (1.3%)

228 (1.0%)

433 (2.0%)

13039 (1.1%)

8313 (1.5%)

Disposable income at birth

 1 (lowest)

322536 (14.0%)

3474 (15.7%)

4199 (19.8%)

137296 (11.9%)

79115 (14.3%)

 2

473269 (20.5%)

5136 (23.2%)

5249 (24.8%)

221609 (19.2%)

132021 (23.8%)

 3

496262 (21.5%)

4886 (22.1%)

4381 (20.7%)

246102 (21.3%)

133214 (24.0%)

 4

507824 (22.0%)

4698 (21.2%)

3988 (18.8%)

265800 (23.0%)

121770 (22.0%)

 5 (highest)

509772 (22.1%)

3933 (17.8%)

3362 (15.9%)

286049 (24.7%)

87890 (15.9%)

Birth order

 1

992824 (43.0%)

8530 (38.6%)

7187 (33.9%)

527609 (45.6%)

207246 (37.4%)

 2

837502 (36.3%)

7782 (35.2%)

7083 (33.4%)

420561 (36.4%)

205141 (37.0%)

 >=3

479337 (20.8%)

5815 (26.3%)

6909 (32.6%)

208686 (18.0%)

141623 (25.6%)

Maternal psychiatric history

115444 (5.0%)

1968 (8.9%)

1414 (6.7%)

56868 (4.9%)

35241 (6.4%)

Mediators

Pregnancy hypertensive diseases

95092 (4.1%)

2930 (13.2%)

1860 (8.8%)

37923 (3.3%)

37311 (6.7%)

Placenta/membrane disorders

112498 (4.9%)

1596 (7.2%)

1341 (6.3%)

56768 (4.9%)

26342 (4.8%)

Gestational infection

82081 (3.6%)

1664 (7.5%)

1172 (5.5%)

41343 (3.6%)

24345 (4.4%)

Intrauterine hypoxia

163647 (7.1%)

2848 (12.9%)

1710 (8.1%)

82377 (7.1%)

45047 (8.1%)

SGA

53530 (2.3%)

485 (2.2%)

387 (1.8%)

25716 (2.2%)

10656 (1.9%)

LGA

75127 (3.3%)

4403 (19.9%)

2646 (12.5%)

28604 (2.5%)

33445 (6.0%)

Labour complications

77562 (3.4%)

1292 (5.8%)

889 (4.2%)

38006 (3.3%)

20748 (3.7%)

Preterm birth

108050 (4.7%)

3225 (14.6%)

1725 (8.1%)

49685 (4.3%)

26713 (4.8%)

Neonatal asphyxia comorbidities

95575 (4.1%)

2529 (11.4%)

1338 (6.3%)

43125 (3.7%)

26814 (4.8%)

Neonatal hematological comorbidities

107856 (4.7%)

2648 (12.0%)

1635 (7.7%)

50096 (4.3%)

30431 (5.5%)

Neonatal hypoglycemia

37130 (1.6%)

3530 (16.0%)

1754 (8.3%)

18457 (1.6%)

14953 (2.7%)

Neonatal infection

76135 (3.3%)

1252 (5.7%)

952 (4.5%)

37333 (3.2%)

22206 (4.0%)

  1. The chi-squared test was used to test for differences in the proportions of each categorical covariate, first across categories of maternal diabetes (no diabetes, PGDM, and GDM) and then across maternal BMI categories (normal weight compared to overweight or obese). P-values were < 0.001 for all covariates, except for the child’s sex, where P = 0.083 (for maternal diabetes) and P = 0.27 (for maternal adiposity)