Table 3 PK parameters of AD16 in MAD groups

T_max,ss (h)

0.62 (0.33–1.00)

0.88 (0.50–4.00)

T_1/2,ss (h)

7.24 ± 1.35 (18.69)

8.50 ± 1.63 (19.15)

C_max,ss (ng/mL)

1127.38 ± 205.57 (18.23)

1528.75 ± 320.96 (20.99)

C_avg,ss (ng/mL)

478.59 ± 100.65 (21.03)

782.98 ± 127.79 (16.32)

C_min,ss (ng/mL)

204.88 ± 73.91 (36.08)

449.63 ± 85.91 (19.11)

AUC_0-τ,ss (h*ng/mL)

5743.12 ± 1207.85 (21.03)

9395.79 ± 1533.46 (16.32)

AUC_0-48 h,ss (h*ng/mL)

8282.70 ± 2266.75 (27.37)

14,737.31 ± 3178.18 (21.57)

AUC_0-∞,ss (h*ng/mL)

8377.29 ± 2338.26 (27.91)

15,061.14 ± 3425.91 (22.75)

CL/F_,ss (mL/h)

5444.94 ± 1210.19 (22.23)

4353.55 ± 679.42 (15.61)

V_d/F_,ss (mL)

55,625.89 ± 10,662.74 (19.17)

52,688.80 ± 9545.88 (18.12)

R_ac,ss (%)

1.36 ± 0.24 (17.81)

1.68 ± 0.19 (11.12)

DF (%)

198.09 ± 50.69 (25.59)

137.29 ± 23.01 (16.76)