Fig. 5

Correlation between metabolites in the second trimester and physical development later in life. A Box plot showing the comparison of height for age, weight for age, BMI for age, and height for weight between the sFGR and MCDA groups. The Mann–Whitney U test was used for nonparametric comparisons between the sFGR and MCDA groups. B The correlation between the metabolites in the second trimester and the standardized development indicators were examined by Spearman correlation analysis. Spearman’s correlation coefficients (R) were used to present the correlations. The shadow around the linear regression trendline shows the 95% confidence interval (CI). The metabolite level in B was determined as Log2-transformed metabolite concentrations (μM); sFGR, selective fetal growth restriction; MCDA, normal monochorionic diamniotic twins; ST, second trimester; CP, cord plasma; MP, maternal plasma; P < 0.05 was considered statistically significant. ns, nonsignificant