Fig. 5

Forest plot for CVD with metabolite composite score. Seven-met, the weighted score obtained from seven metabolites, TAG 50:2, TAG 50:1, TAG 48:1, TAG 48:0, TAG 46:0, PC 32:1, and glutamine; three-met, the weighted score obtained from three metabolites, TAG 52:3, isoleucine, and leucine. Weights were obtained from the beta coefficients of association test between cumulative average alcohol consumption and metabolites in linear mixed models. In the Cox regression, base model included age, sex, and batch as covariates, and multivariable model additionally adjusted for BMI, SBP, hypertension treatment status, diabetes, smoking status, and total and high-density lipoprotein cholesterol level