Table 1 Characteristics of 6800 brain tumour patients and their 33,785 age, sex and GP practice-matched controls by tumour behaviour
All primary brain tumours | Malignant brain tumours | Non-malignant brain tumours | |||||||
|---|---|---|---|---|---|---|---|---|---|
Overall N (%) | Cases N (%) | Controls N (%) | Overall N (%) | Cases N (%) | Controls N (%) | Overall N (%) | Cases N (%) | Controls N (%) | |
Number of participants | 40,585 | 6800 | 33,785 | 17,140 | 2869 | 14,271 | 23,445 | 3931 | 19,514 |
Age (median; IQR) | 63 (49, 75) | 63 (49, 74) | 63.0 (49, 75) | 64 (52, 74) | 64 (52, 74) | 64 (52, 74) | 62 (40, 76) | 62 (47, 75) | 62 (47, 76) |
Age-group | |||||||||
18–50 years | 10,366 (25.5) | 1751 (25.8) | 8615 (25.5) | 3631 (21.2) | 610 (21.3) | 3021 (21.2) | 6735 (28.7) | 1141 (29.0) | 5594 (28.7) |
50–54 years | 3078 (7.6) | 525 (7.7) | 2553 (7.6) | 1295 (7.6) | 226 (7.9) | 1069 (7.5) | 1783 (7.6) | 299 (7.6) | 1484 (7.6) |
55–59 years | 3716 (9.2) | 653 (9.6) | 3063 (9.1) | 1661 (9.7) | 286 (10.0) | 1375 (9.6) | 2055 (8.8) | 367 (9.3) | 1688 (8.7) |
60–64 years | 4188 (10.3) | 693 (10.2) | 3495 (10.3) | 2022 (11.8) | 336 (11.7) | 1686 (11.8) | 2166 (9.2) | 357 (9.1) | 1809 (9.3) |
65–69 years | 4543 (11.2) | 801 (11.8) | 3742 (11.1) | 2297 (13.4) | 419 (14.6) | 1878 (13.2) | 2246 (9.6) | 382 (9.7) | 1864 (9.6) |
70–74 years | 4118 (10.1) | 684 (10.1) | 3434 (10.2) | 2063 (12.0) | 333 (11.6) | 1730 (12.1) | 2055 (8.8) | 351 (8.9) | 1704 (8.7) |
75–79 years | 4051 (10.0) | 643 (9.5) | 3408 (10.1) | 1868 (10.9) | 293 (10.2) | 1575 (11.0) | 2183 (9.3) | 350 (8.9) | 1833 (9.4) |
80–84 years | 3474 (8.6) | 568 (8.4) | 2906 (8.6) | 1425 (8.3) | 238 (8.3) | 1187 (8.3) | 2049 (8.7) | 330 (8.4) | 1719 (8.8) |
85 + years | 3051 (7.5) | 482 (7.1) | 2569 (7.6) | 878 (5.1) | 128 (4.5) | 750 (5.3) | 2173 (9.3) | 354 (9.0) | 1819 (9.3) |
Sex | |||||||||
Male | 18,847 (46.4) | 3159 (46.5) | 15,688 (46.4) | 9854 (57.5) | 1650 (57.5) | 8204 (57.5) | 8993 (38.4) | 1509 (38.4) | 7484 (38.4) |
Female | 21,738 (53.6) | 3641 (53.5) | 18,097 (53.6) | 7286 (42.5) | 1219 (42.5) | 6067 (42.5) | 14,452 (61.6) | 2422 (61.6) | 12,030 (61.6) |
Year of study entry | |||||||||
2000–2004 | 10,318 (25.4) | 1730 (25.4) | 8588 (25.4) | 4942 (28.8) | 828 (28.9) | 4114 (28.8) | 5376 (22.9) | 902 (22.9) | 4474 (22.9) |
2005–2009 | 13,619 (33.6) | 2280 (33.5) | 11,339 (33.6) | 5633 (32.9) | 942 (32.8) | 4691 (32.9) | 7986 (34.1) | 1338 (34.0) | 6648 (34.1) |
2010–2014 | 16,648 (41.0) | 2790 (41.0) | 13,858 (41.0) | 6565 (38.3) | 1099 (38.3) | 5466 (38.3) | 10,083 (43.0) | 1691 (43.0) | 8392 (43.0) |
WIMD | |||||||||
I (most deprived) | 8293 (20.7) | 1318 (19.6) | 6975 (20.9) | 3413 (20.1) | 528 (18.6) | 2885 (20.5) | 4880 (21.0) | 790 (20.3) | 4090 (21.2) |
II | 8062 (20.1) | 1313 (19.5) | 6749 (20.2) | 3339 (19.7) | 529 (18.6) | 2810 (19.9) | 4723 (20.4) | 784 (20.1) | 3939 (20.4) |
III | 8290 (20.7) | 1395 (20.7) | 6895 (20.6) | 3543 (20.9) | 586 (20.6) | 2957 (21.0) | 4747 (20.5) | 809 (20.7) | 3938 (20.4) |
IV | 7500 (18.7) | 1302 (19.3) | 6198 (18.6) | 3200 (18.9) | 572 (20.2) | 2628 (18.6) | 4300 (18.5) | 730 (18.7) | 3570 (18.5) |
V (least deprived) | 8000 (19.9) | 1410 (20.9) | 6590 (19.7) | 3446 (20.3) | 623 (22.0) | 2823 (20.0) | 4554 (19.6) | 787 (20.2) | 3767 (19.5) |
Unknown | 440 | 62 | 378 | 199 | 31 | 168 | 241 | 31 | 210 |
Past medical history | |||||||||
Hypertension | 12,710 (31.3) | 2185 (32.1) | 10,525 (31.2) | 5423 (31.6) | 876 (30.5) | 4547 (31.9) | 7287 (31.1) | 1309 (33.3) | 5978 (30.6) |
Diabetes mellitus | 4454 (11.0) | 676 (9.9) | 3778 (11.2) | 1973 (11.5) | 254 (8.9) | 1719 (12.0) | 2481 (10.6) | 422 (10.7) | 2059 (10.6) |
Hyperlipidaemia | 10,759 (26.5) | 1772 (26.1) | 8987 (26.6) | 4683 (27.3) | 717 (25.0) | 3966 (27.8) | 6076 (25.9) | 1055 (26.8) | 5021 (25.7) |
Heavy alcohol use | 1123 (2.8) | 123 (1.8) | 1000 (3.0) | 519 (3.0) | 64 (2.2) | 455 (3.2) | 604 (2.6) | 59 (1.5) | 545 (2.8) |
Major vascular events | 5914 (14.6) | 966 (14.2) | 4948 (14.6) | 2695 (15.7) | 444 (15.5) | 2251 (15.8) | 3219 (13.7) | 522 (13.3) | 2697 (13.8) |
Venous thromboembolism | 964 (2.4) | 174 (2.6) | 790 (2.3) | 385 (2.2) | 64 (2.2) | 321 (2.2) | 579 (2.5) | 110 (2.8) | 469 (2.4) |
Medication | |||||||||
Antihypertensive drug(s) | 13,524 (33.3) | 2251 (33.1) | 11,273 (33.4) | 5845 (34.1) | 931 (32.5) | 4914 (34.4) | 7679 (32.8) | 1320 (33.6) | 6359 (32.6) |
Antiplatelet drug(s) | 8230 (20.3) | 1249 (18.4) | 6981 (20.7) | 3544 (20.7) | 483 (16.8) | 3061 (21.4) | 4686 (20.0) | 766 (19.5) | 3920 (20.1) |
Anticoagulant drug(s) | 1903 (4.7) | 260 (3.8) | 1643 (4.9) | 831 (4.8) | 94 (3.3) | 737 (5.2) | 1072 (4.6) | 166 (4.2) | 906 (4.6) |