Table 2 Association of metabolic-obesity phenotypes at < 60, 60 to < 70, and ≥ 70 years with incidence of dementia

At age < 60 years^a, median (IQR) follow-up 20.8 (15.5, 26.4) years

 N dementia cases/total

217/4301

123/1715

33/503

37/590

 Rate/1000 person-years

2.51

3.64

3.62

3.46

Models, HR (95% CI)

 Model 1^d

Ref

1.43 (1.14, 1.79)

1.71 (1.18, 2.49)

1.54 (1.09, 2.20)

 Model 2^e

Ref

1.38 (1.10, 1.73)

1.69 (1.16, 2.45)

1.46 (1.02, 2.08)

At ages 60 years to < 70 years^b, median (IQR) follow-up 10.3 (6.3, 15.4) years

 N dementia cases/total

183/3117

127/2067

23/433

46/795

 Rate/1000 person-years

5.20

5.92

5.02

6.11

Models, HR (95% CI)

 Model 1^d

Ref

1.28 (1.02, 1.62)

1.06 (0.68, 1.64)

1.54 (1.11, 2.14)

 Model 2^e

Ref

1.28 (1.01, 1.61)

1.02 (0.65, 1.58)

1.47 (1.05, 2.04)

At age ≥ 70 years^c, median (IQR) follow-up 4.2 (3.1, 7.1) years

 N dementia cases/total

83/1244

121/1589

14/191

44/540

 Rate/1000 person-years

11.33

13.24

13.18

14.63

Models, HR (95% CI)

 Model 1^d

Ref

1.18 (0.89, 1.56)

1.09 (0.61, 1.94)

1.28 (0.88, 1.85)

 Model 2^e

Ref

1.16 (0.87, 1.53)

0.99 (0.56, 1.78)

1.20 (0.82, 1.74)