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Fig. 4 | BMC Medicine

Fig. 4

From: Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis

Fig. 4

Male-specific risk factors of dementia or cognitive decline. The factor included in the middle-aged was ED (1), and factors included in the elderly were sorted into disease-related factors and sex hormones in the elderly (2). They are listed in the order of RR values on the main outcome from least to most. The patchwork patterns by circle and square represent RR, and the horizontal lines across the spot represent 95% CI. Abbreviations: ADT: androgen deprivation therapy, CI: confidence interval, E2: estradiol, GnRH: gonadotropin-releasing hormone, RR: relative risk, SHBG: sex hormone–binding globulin, T: testosterone, WQS: weighted-NOS score. * Refers to the results compared to prostate cancer patients without ADT, ** refers to the results compared to normal healthy people without prostate cancer

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