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Fig. 3 | BMC Medicine

Fig. 3

From: Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression

Fig. 3

Influence of hormonal treatment on endometrial gene expression. Volcano plots showing a differential gene expression between the proliferative and secretory stage identified 1791 genes that were significantly upregulated and 1044 genes that were significantly downregulated. A comparison of the medicated samples compared to the b proliferative stage and c the secretory stage found only 1102 and 77 genes differentially regulated respectively. d Violin plots showing the fold change of genes influenced by medication including FAM125B, WNT7A and FKBP5 that showed similar regulation between medicated and secretory samples. e Pathway analysis using the gene set enrichment analysis (GSEA) identified medication influenced immune system pathways in endometrium tissue. The top four pathways for each comparison are shown in the dotplot. The size of the dot is relative to ratio of gene enrichment and the colour shows the significance of the enrichment as a − log10 adjusted p-value

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BMC Medicine

ISSN: 1741-7015

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