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Fig. 4 | BMC Medicine

Fig. 4

From: Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression

Fig. 4

Gene expression profiles of endometrial lesions. a PCA of gene expression variability in all endometriotic lesions coloured by menstrual cycle phase at sample collection. No association between gene expression and the menstrual stage was observed. b PCA analysis of all samples coloured by lesion subtype. A significant separation by lesion subtype was observed. c Heatmap of genes differentially expressed between lesion subtypes. Comparison of gene expression clearly indicated samples clustered predominantly based on lesion subtype. List of genes used for sample clustering is available in Tables S4, S5 and S6. d Analysis of biological pathways enriched for genes differentially expressed between different subtypes (SUP, OMA, DIE). Samples from DIE displayed an increased response to antigens, whereas OMA showed a negative regulation of growth

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BMC Medicine

ISSN: 1741-7015

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