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Fig. 4 | BMC Medicine

Fig. 4

From: A novel approach to risk exposure and epigenetics—the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health

Fig. 4

Comparison of models using DNAm patterns versus clinical variables using RF. Boxplot of importance scores (y-axis) of variables (x-axis) predicting waist circumference at age 10 using three different models (panels A–C). A Model 1 using individual MRP-related variables. B Model 2 using MRP dimensions from factor analysis. C Model 3 using gwDNAm patterns in cord blood. The x-axis includes additional control variables of estimated blood cell type proportions. Inset: Sample size and performance metrics for each model. Boxes appearing to the right of the grey vertical line (i.e. after the maximum randomised shadow variable) indicate relevant variables. The box and whiskers display the distribution of permutation values and cannot be used to tell statistical significance [31]. Blue—Dimension 1 (smoking in grandmother), orange—Dimension 3 (smoking in father + household + grandfather + mother), green—Dimension 4 (smoking in mother + birth weight), pink—Dimension 5 (smoking in household + mother + birth weight)

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BMC Medicine

ISSN: 1741-7015

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