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Fig. 8 | BMC Medicine

Fig. 8

From: A novel approach to risk exposure and epigenetics—the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health

Fig. 8

Chromatin mark enrichment analysis using LOLA. X-axis: Enrichment rank where lower numbers indicate higher rank and thus stronger evidence of enrichment. Colours represent the source of DNAm candidates. Tissue/cell cultures demonstrating a specific chromatin mark are labelled on the y-axis. Cells sharing embryonic lineage are grouped together where applicable. Sites from a given DNAm pattern (i.e. same colour circles) tend to have two or more clusters with common lineages, as represented by circles falling on the same or nearby horizontal lines. In contrast, meta-EWAS candidates [44] represented by dark purple circles appear scattered across unrelated lineages. Granulocyte colony-stimulating factor, G-CSF; phorbol myristate acetate–ionomycin, PMA-I; human embryonic stem cell line, H1; induced pluripotent stem line derived from foreskin fibroblasts, iPS DF; human embryonic stem cell line, HUES

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BMC Medicine

ISSN: 1741-7015

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