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Fig. 9 | BMC Medicine

Fig. 9

From: A novel approach to risk exposure and epigenetics—the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health

Fig. 9

Overlap of gwDNA methylation patterns with meta-EWAS candidates [44]. Histogram shows the number of EWAS candidates that match sites within DNAm components (patterns). The dark grey bars highlight seven DNAm components that we dismissed because they relate strongly with the confounders of sex and/or cell composition. Components related to confounders were also found to be frequently related to health outcomes. Among 1183 overlaps, 566 overlapped with these components (dark grey bars), 749 represented unique CpG sites, and 474 localised to unique genes. A large proportion of gwDNAm pattern representative sites “consistent” with this EWAS were related to Component 4. Recall that this component was related to subject sex and was the most strongly correlated component with the maternal smoking-related MRP, Dimension 2

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BMC Medicine

ISSN: 1741-7015

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