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Fig 6 | BMC Medicine

Fig 6

From: Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders

Fig 6

Disruption of rs4558409 promotes neural development and vesicle trafficking. A, B Effects of rs4558409-KO (KO) on PLLP RNA (A) and protein (B) expression levels in SK-N-SH cells. **p< 0.01 and ****p < 0.0001 from two-tailed Student’s t test. The relative intensity of binding as determined via Western blot analysis is shown underneath each band. C rs4558409-KO promoted neural development of SK-N-SH cells without or with ATRA treatment. The scale bar represents 100 μm. D Neurite-like length of the wild-type (WT, orange) or rs4558409-KO (KO, red) SK-N-SH cells without (solid) or with ATRA treatment (hatched). ****p<0.0001 from one-way ANOVA with Tukey’s multiple comparisons test. E FM4-64 imaging analysis of the wild-type (WT, orange) or rs4558409-KO (KO, red) SK-N-SH cells. ****p< 0.0001 obtained from two-way ANOVA. F Functional enrichment analysis of rs4854158-KO-induced DEGs in SK-N-SH cells

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BMC Medicine

ISSN: 1741-7015

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