Fig. 1

A The 100 most abundant RNAs in plasma EVs in normotensive controls (n=7) from the RNA-seq analysis at 22–24 weeks and 36–38 weeks gestation. B Volcano plot and distribution of differentially expressed RNAs from plasma extracellular vesicles are shown between women with preeclampsia (PE) (n=7) and normotensive controls (n=7) at gestational weeks 36–38 (B), and between gestational weeks 22–24 and 36–38 in women who subsequently developed PE (D). The distribution (number and percentage) of the different classes of differentially regulated RNA and lncRNA are shown between PE and normotensive pregnancies (C) and between gestational weeks 22–24 and 36–38 in women who subsequently developed PE (E). *divergent/overlapping/intronic