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Fig. 4 | BMC Medicine

Fig. 4

From: Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

Fig. 4

Causal relationships between testosterone, endometriosis and clear cell carcinoma ovarian cancer determined by Mendelian randomisation. A causal effect of testosterone and bioavailable testosterone on endometriosis is supported by multiple methods. A causal effect of bioavailable testosterone on clear cell carcinoma ovarian cancer was identified using univariate approaches, but adjustment for endometriosis using multivariable MR attenuated the effect and it was non-significant. MR: Mendelian randomisation, GSMR: generalised summary Mendelian randomisation, SHBG: sex hormone-binding globulin, IVW: inverse-variance weighted. MR-PRESSO: Mendelian Randomization Pleiotropy Residual Sum and Outlier

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BMC Medicine

ISSN: 1741-7015

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