Clinical efficacy of sodium bicarbonate in treating pediatric metabolic acidosis with varying level of acid–base balance parameters: a real-world study

Table 5 Risk of mortality in children treated with sodium bicarbonate stratified by chloride level after matching confounding factors

Subgroups (mmol/L)	Endpoint	Treatment	Death, n (%)		p	OR (95% CI)
Subgroups (mmol/L)	Endpoint	Treatment	No	Yes	p	OR (95% CI)
Cl⁻ < 107	Death in hospital	With SB	191 (71.54)	76 (28.46)	0.011	1.685 (1.124, 2.526)
	Death in hospital	Without SB	216 (80.90)	51 (19.10)		1
	28-day death	With SB	198 (74.16)	69 (25.84)	0.015	1.674 (1.101, 2.547)
	28-day death	Without SB	221 (82.77)	46 (17.23)		1
107 ≤ Cl⁻ < 113	Death in hospital	With SB	414 (92.62)	33 (7.38)	1.000	1.000 (0.606, 1.651)
	Death in hospital	Without SB	414 (92.62)	33 (7.38)		1
	28-day death	With SB	419 (93.74)	28 (6.26)	0.779	1.082 (0.624, 1.877)
	28-day death	Without SB	421 (94.18)	26 (5.82)		1
Cl⁻ ≥ 113	Death in hospital	With SB	422 (96.35)	16 ( 3.65)	0.001	0.367(0.203, 0.665)
	Death in hospital	Without SB	397 (90.64)	41 ( 9.36)		1
	28-day death	With SB	422 (96.35)	16 ( 3.65)	0.012	0.465 (0.252, 0.858)
	28-day death	Without SB	405 (92.47)	33 ( 7.53)		1

Notation: SB Sodium bicarbonate, AG Anion gap, OR The odds ratio of death for children treated with SB as compared to those without; confounding factors such as age, sepsis, pneumonia, meningoencephalitis, surgery, disease diagnosis, pH, Cl⁻, Ca²⁺, K⁺, Na⁺, lactate, PaCO_2, total bilirubin, triglyceride, total protein, hemoglobin, red blood cell, and white blood cell were matched

ISSN: 1741-7015