Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

Table 1 Descriptive statistics of the FinnTwin12 and NTR cohorts

Four longitudinal measurements with ~ 10 and ~ 6 years of follow-up were collected in the FinnTwin12 and NTR cohorts, respectively. Time points marked with (*) included blood sampling from which proteomic, metabolomic, and polygenic risk score data were derived. Intercepts and slopes were obtained by Latent Growth Curve Models, in a logarithmic scheme for FinnTwin12 and linear scheme for NTR. Final samples included 651 participants (female 59%) for FinnTwin12 and 665 (female 69%) for NTR. In FinnTwin12, BMI at baseline and last BMI measurement (wave 22) ranged 11.0–30.1 and 17.2–42.0 respectively. In NTR, BMI at baseline and last BMI measurement (bb1) ranged 15.2–40.3 and 15.8–51.3 respectively. BMI is expressed as kg/m² and age as years
NTR Netherlands Twin Register, N Number of participants without missing value, sd Standard deviation

ISSN: 1741-7015