Table 2 Subgroup analysis of prognostic role of LMR for overall survival in patients with glioma

Total

15

2999

Random

1.35 (1.13–1.61)

0.001

64.9

 < 0.001

Country

0.059

 China

13

2913

Random

1.28 (1.08–1.51)

0.005

62.1

0.001

 Others

2

86

Fixed

2.46 (1.47–4.14)

0.001

25.4

0.247

Sample size

0.156

  < 200

9

1143

Random

1.56 (1.19–2.04)

0.001

61.4

0.008

  ≥ 200

6

1856

Random

1.16 (0.94–1.43)

0.166

62.0

0.022

Histological type

0.646

 Glioma

10

2214

Random

1.42 (1.09–1.85)

0.009

72.2

 < 0.001

 GBM

5

785

Fixed

1.23 (1.07–1.42)

0.003

46.2

0.114

Treatment

0.241

 Surgery

5

1166

Fixed

1.16 (0.96–1.39)

0.124

0

0.535

 Mixed

10

1833

Random

1.49 (1.17–1.91)

0.002

75.0

 < 0.001

Cut-off value

0.536

  ≤ 3.7

8

1763

Fixed

1.31 (1.15–1.48)

 < 0.001

46.2

0.072

  > 3.7

7

1236

Random

1.28 (0.92–1.77)

0.140

76.4

 < 0.001

Cut-off determination

0.559

 X-tile

3

842

Fixed

1.22 (0.98–1.53)

0.081

16.8

0.301

 ROC curve

12

2157

Random

1.40 (1.13–1.74)

0.002

70.6

 < 0.001

Survival analysis

0.960

 Univariate

13

2593

Random

1.35 (1.12–1.63)

0.002

66.2

 < 0.001

 Multivariate

2

406

Random

1.45 (0.66–3.15)

0.352

76.9

0.037