Fig. 4
Correlation analysis between PLS1 weighted gene expressions of changes in MSN strength and transcriptional dysregulation of various mental disorders. a-b. In EOS1 patients, PLS1- weights exhibited significant positive associations with upregulated differential gene expression (DGE) in autism spectrum disorder (ASD) (rs (106) = 0.29, adjusted pperm = 0.006) and adult schizophrenia (rs(127) = 0.24, adjusted pperm = 0.007). c-e. There was no significant correlation with DGE in other mental disorders in EOS1 patients, including bipolar disorder (BD) (rs(35) = -0.10, adjusted pperm = 0.709), alcohol abuse disorder (AAD) (rs(41) = 0.16, adjusted pperm = 0.171) and inflammatory bowel disease (IBD) (rs(418) = 0.03, adjusted pperm = 0.306). f. In EOS2 patients, PLS1- weights exhibited significant positive associations with upregulated DGE in IBD (rs(70) = 0.33, adjusted pperm = 0.011). All r values were determined by Spearman’s correlation analysis, and p values were obtained from permutation tests and adjusted with FDR correction