Fig. 6
Cellular specific transcriptional signatures in accordance with MSN changes in EOS subtypes. a. The distribution of regional gene expression maps of seven brain cells using ssGSEA scores. b. The number of overlapping genes with PLS1 + weighted genes for each cell type, including inhibitory neurons (number = 25, adjusted pperm = 0.021); excitatory neurons (number = 22, adjusted pperm = 0.006); endothelial cells (number = 25, adjusted pperm = 1); microglia (number = 8, adjusted pperm = 0.825); astrocytes (number = 8, adjusted pperm = 1); oligodendrocytes (number = 2, adjusted pperm = 1); oligodendrocyte precursors (OPCs) (number = 2, adjusted pperm = 1). c. Gene ontology and pathway terms enriched for PLS1 + weighted genes for different cell types. d. The number of overlapping genes with PLS1- weighted genes for each cell type, including inhibitory neurons (number = 17, adjusted pperm = 0.9243); excitatory neurons (number = 9, adjusted pperm = 1); endothelial cells (number = 30, adjusted pperm = 0.9243); microglia (number = 4, adjusted pperm = 1); astrocytes (number = 28, adjusted pperm = 0.019); oligodendrocytes (number = 2, adjusted pperm = 1); and oligodendrocyte precursors (OPCs) (number = 6, adjusted pperm = 0.9243). e. Gene ontology and pathway terms enriched for PLS1- weighted genes for different cell types. All p values were obtained from permutation tests and adjusted with FDR correction