Association of genetic risk and lifestyle with pancreatic cancer and their age dependency: a large prospective cohort study in the UK Biobank

Table 2 Association between PRS, lifestyles, and risk of PC

Characteristics	PC/non-PC	Model 1^a				Model 2^a
Characteristics	PC/non-PC	HR (95% CI)	P value	HR (95% CI)	P value for trend ^c	HR (95% CI)	P value	HR (95% CI)	P value for trend ^c
PRS				1.58 (1.46–1.70)	1.45E-32			1.58 (1.47–1.71)	5.78E-33
Low	217/113,308	0.60 (0.50–0.70)	1.56E-09			0.59 (0.50–0.70)	1.23E-09
Intermediate ^b	364/113,207	1 [Reference]	NA			1 [Reference]	NA
High	548/112,987	1.51 (1.32–1.72)	1.31E-09			1.51 (1.32–1.73)	9.96E-10
Weighted healthy lifestyle score				0.67 (0.62–0.72)	6.65E-26			0.69 (0.64–0.74)	8.79E-22
Unfavorable	526/112,905	1 [Reference]	NA			1 [Reference]	NA
Intermediate	361/113,497	0.67 (0.59–0.77)	6.86E-09			0.66 (0.58–0.76)	2.40E-09
Favorable	242/113,100	0.45 (0.39–0.52)	9.36E-25			0.48 (0.41–0.56)	1.69E-20
Unweighted healthy lifestyle score				0.72 (0.67–0.78)	4.30E-19			0.78 (0.72–0.84)	1.63E-11
Unfavorable	509/116,096	1 [Reference]	NA			1 [Reference]	NA
Intermediate	339/101,907	0.75 (0.65–0.86)	3.60E-05			0.81 (0.70–0.93)	2.23E-03
Favorable	281/121,499	0.52 (0.45–0.60)	8.57E-19			0.60 (0.52–0.70)	1.98E-11

Abbreviations: PC Pancreatic cancer, PRS Polygenic risk score, HR Hazard ratio, NA Not applicable
^aModel 1 was not adjusted; model 2 was adjusted for age (continuous), sex, education level, socioeconomic status, and the first 5 principal components of ancestry
^bSet the intermediate value of PRS as the reference
^c P value for trend was determined by using the categorical variables as continuous

ISSN: 1741-7015