Table 3 Associations of lifestyle components with incident PC according to PRS stratified analysisa
Characteristics | PRS | P value for interaction | |||||
|---|---|---|---|---|---|---|---|
Low | Intermediate | High | |||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||
BMI (kg/m2) | Â | Â | Â | Â | Â | Â | 0.827 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.74 (0.54–1.01) | 0.058 | 0.78 (0.61–1.01) | 0.053 | 0.88 (0.72–1.07) | 0.192 |  |
 Favorable | 0.61 (0.42–0.87) | 0.007 | 0.73 (0.55–0.96) | 0.025 | 0.70 (0.56–0.89) | 0.003 |  |
Waist circumference (cm) | Â | Â | Â | Â | Â | Â | 0.965 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.88 (0.63–1.23) | 0.454 | 0.81 (0.62–1.04) | 0.102 | 0.78 (0.63–0.96) | 0.018 |  |
 Favorable | 0.78 (0.57–1.07) | 0.126 | 0.74 (0.58–0.95) | 0.018 | 0.66 (0.54–0.81) |  < 0.001 |  |
Physical activity 10 + min (days/week) |  |  |  |  |  |  | 0.461 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.95 (0.62–1.46) | 0.805 | 0.96 (0.69–1.33) | 0.788 | 0.88 (0.66–1.16) | 0.351 |  |
 Favorable | 0.78 (0.50–1.21) | 0.268 | 0.80 (0.57–1.12) | 0.198 | 0.94 (0.71–1.23) | 0.643 |  |
Sedentary time (hours/day) | Â | Â | Â | Â | Â | Â | 0.153 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.65 (0.48–0.88) | 0.006 | 0.89 (0.71–1.12) | 0.329 | 0.85 (0.71–1.02) | 0.075 |  |
 Favorable | 0.67 (0.43–1.05) | 0.078 | 1.03 (0.76–1.41) | 0.838 | 0.61 (0.46–0.82) | 0.001 |  |
Total fruit and vegetable intake | Â | Â | Â | Â | Â | Â | 0.369 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 1.04 (0.76–1.43) | 0.809 | 0.75 (0.59–0.95) | 0.019 | 0.97 (0.79–1.18) | 0.750 |  |
 Favorable | 0.97 (0.68–1.39) | 0.867 | 0.79 (0.61–1.04) | 0.088 | 0.90 (0.72–1.13) | 0.354 |  |
Whole grains intake | Â | Â | Â | Â | Â | Â | 0.924 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.75 (0.53–1.05) | 0.095 | 0.90 (0.69–1.18) | 0.433 | 0.89 (0.72–1.11) | 0.317 |  |
 Favorable | 0.75 (0.52–1.09) | 0.133 | 0.83 (0.62–1.12) | 0.222 | 0.85 (0.67–1.08) | 0.186 |  |
Red meat and processed meat intake | Â | Â | Â | Â | Â | Â | 0.718 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.88 (0.64–1.20) | 0.409 | 1.04 (0.82–1.31) | 0.752 | 1.10 (0.90–1.33) | 0.349 |  |
 Favorable | 0.84 (0.59–1.19) | 0.323 | 0.80 (0.60–1.06) | 0.120 | 0.93 (0.74–1.16) | 0.512 |  |
Alcohol intake frequency | Â | Â | Â | Â | Â | Â | 0.457 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.98 (0.71–1.37) | 0.924 | 0.95 (0.74–1.22) | 0.677 | 0.76 (0.62–0.93) | 0.008 |  |
 Favorable | 0.97 (0.66–1.42) | 0.864 | 0.92 (0.69–1.24) | 0.600 | 0.88 (0.69–1.11) | 0.263 |  |
Smoking | Â | Â | Â | Â | Â | Â | 0.568 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.49 (0.33–0.73) |  < 0.001 | 0.66 (0.47–0.92) | 0.013 | 0.53 (0.41–0.68) |  < 0.001 |  |
 Favorable | 0.45 (0.30–0.66) |  < 0.001 | 0.62 (0.44–0.85) | 0.004 | 0.42 (0.33–0.54) |  < 0.001 |  |
Unweighted healthy lifestyle score | Â | Â | Â | Â | Â | Â | 0.645 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.93 (0.68–1.26) | 0.626 | 0.72 (0.56–0.92) | 0.008 | 0.82 (0.68–1.01) | 0.058 |  |
 Favorable | 0.57 (0.40–0.81) | 0.002 | 0.59 (0.46–0.77) |  < 0.001 | 0.62 (0.50–0.76) |  < 0.001 |  |
Weighted healthy lifestyle score | Â | Â | Â | Â | Â | Â | 0.679 |
 Unfavorable | 1 [Reference] | NA | 1 [Reference] | NA | 1 [Reference] | NA |  |
 Intermediate | 0.70 (0.52–0.95) | 0.022 | 0.63 (0.50–0.81) |  < 0.001 | 0.68 (0.56–0.82) |  < 0.001 |  |
 Favorable | 0.49 (0.35–0.70) |  < 0.001 | 0.55 (0.43–0.72) |  < 0.001 | 0.44 (0.35–0.55) |  < 0.001 |  |