Fig. 6

PDGF-AB levels in all subjects validated by ELISA. PDGF-AB levels at baseline, pre-, and post-hypoxia in each group are presented. All intervention groups exhibited a decrease in PDGF-AB levels from baseline to pre-hypoxia, followed by an increase in levels after hypoxic exposure. The pre-hypoxic PDGF-AB levels in Ripc (P = 0.014), Rapid-Ripc (P < 0.001), Acetazolamide (P = 0.018), and Combined groups (P = 0.010) were significantly lower than those in Control group. Data are presented in box-whisker plots using Tukey method: the box extends from the 25th to 75th percentiles, and the line in the middle of the box represents the median. The upper whisker refers to the 75th percentile plus 1.5 times inter-quartile distance (IQD), and the lower whisker refers to the 25th percentile minus 1.5 IQD. Outliers are plotted individually. Statistical analyses included all the individual values. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001