Fig. 1

Maternal sevoflurane exposure increases the epilepsy susceptibility of adolescent offspring. A Experimental procedures. B Quantification of total body weight in the two groups. C Illustrations of representative mice behaviors for respective seizure scores according to the Racine scale. D Overall PTZ injections to induce seizures in Ctr and Sevo groups respectively. Note the lower number of PTZ injections for inducing tonic-clonic seizures in the Sevo group. E–H Comparisons about the latency to induce minimal seizures (E), the cumulative doses and the latencies required to induce the 1st tonic-clonic seizures (F, G), and the intervals between minimal and tonic-clonic seizures (H). The data are represented as mean ± SEM. Ctr: n=12; Sevo: n=12. Two-tailed Student’s t-test was performed for statistical analysis. **p < 0.01, ***p < 0.001, n.s. no significance