| Non-drinkers (n = 114,528) | Mild-to-moderate drinkers (n = 207,254) | Heavy drinkers (n = 77,547) | P-value |
---|---|---|---|---|
Demographic data | ||||
 Age, years | 57.0±8.2 | 56.9±8.0 | 56.4±79 | <0.001 |
 Sex, % | 36,978 (32.3) | 83,621 (40.3) | 61,382 (79.2) | <0.001 |
 BMI, kg/m2 | 28.2±5.5 | 26.7±4.4 | 27.8±4.2 | <0.001 |
Past medical history, % | ||||
 Hypertension | 32,398 (28.3) | 48,433 (23.4) | 24,048 (31.0) | <0.001 |
 Diabetes mellitus | 7014 (6.1) | 5998 (2.9) | 3336 (4.0) | <0.001 |
 Myocardial infarction | 6993 (6.1) | 9237 (4.5) | 5139 (6.6) | <0.001 |
 Dyslipidemia | 14,528 (12.7) | 21,954 (10.6) | 1168 (14.4) | <0.001 |
 Chronic kidney disease | 6791 (5.9) | 7182 (3.5) | 2722 (3.5) | <0.001 |
 Heart failure | 4528 (4.0) | 5134 (2.5) | 2888 (3.7) | <0.001 |
 Stroke | 2689 (2.3) | 3823 (1.8) | 1943 (2.5) | <0.001 |
Physical examination | ||||
 SBP, mmHg | 137.0±18.8 | 137.4±18.5 | 142.8±18.0 | <0.001 |
 DBP, mmHg | 81.3±10.1 | 81.8±9.9 | 85.3±10.0 | <0.001 |
Smoking, % | Â | Â | Â | <0.001 |
 Never smoker | 69,351 (60.8) | 120,481 (58.3) | 28,467 (37.0) |  |
 Ex-smoker | 32,184 (28.2) | 71,657 (34.7) | 35,468 (46.1) |  |
 Current smoker | 12,514 (11.0) | 14,508 (7.0) | 13,056 (17.0) |  |
PRS for alcohol use | 0.011±0.021 | 0.012±0.020 | 0.013±0.019 | <0.001 |