Table 2 Baseline characteristics classified by genetic predisposition to alcohol metabolism according to PRS
| Â | Low tertile (n = 133,054) | Middle tertile (n = 132,363) | High tertile (n = 133,912) | P-value |
|---|---|---|---|---|
Demographic data | ||||
 Age, years | 56.9±8.0 | 56.8±8.0 | 56.8±8.0 | 0.015 |
 Sex, % | 60,811(45.7) | 60,469 (45.7) | 60,701 (45.3) | <0.091 |
 BMI, kg/m2 | 27.3±4.7 | 27.4±4.7 | 27.4±4.8 | <0.001 |
Past medical history, % | ||||
 Hypertension | 34,487 (25.9) | 34,950 (26.4) | 35,442 (26.5) | 0.002 |
 Diabetes mellitus | 5273 (4.0) | 5340 (4.0) | 5535 (4.1) | 0.081 |
 Myocardial infarction | 7010 (5.3) | 6993 (5.3) | 7366 (5.5) | 0.012 |
 Dyslipidemia | 15,740 (11.8) | 15,971 (12.1) | 15,939 (11.9) | 0.157 |
 Chronic kidney disease | 5644 (4.2) | 5505 (4.2) | 5546 (4.1) | 0.384 |
 Heart failure | 4132 (3.1) | 4183 (3.2) | 4235 (#.2) | 0.634 |
 Stroke | 2744 (2.1) | 2836 (2.1) | 2875 (2.1) | 0.233 |
Physical examination | ||||
 SBP, mmHg | 138.2±18.5 | 138.4±18.7 | 138.4±18.7 | <0.001 |
 DBP, mmHg | 82.2±10.1 | 82.3±10.1 | 82.4±10.1 | <0.001 |
Smoking, % | Â | Â | Â | 0.169 |
 Never smoker | 72,788 (54.9) | 72,298 (54.8) | 73,213 (54.8) |  |
 Ex-smoker | 46,598 (35.2) | 46,241 (35.1) | 46,770 (35.0) |  |
 Current smoker | 13,182 (9.9) | 13,388 (10.1) | 13,508 (10.1) |  |
Alcohol consumption, unit/day | 2.1±2.7 | 2.2±2.8 | 2.3±2.9 | <0.001 |