Risk of newly developed atrial fibrillation by alcohol consumption differs according to genetic predisposition to alcohol metabolism: a large-scale cohort study with UK Biobank

Table 3 Associations of alcohol consumption habit and PRS for alcohol metabolism with atrial fibrillation

Variables	Total number	Atrial fibrillation	Incidence rates	Unadjusted HR (95% CI)	P-value	Adjusted HR^a (95% CI)	P-value
Alcohol consumption habit
Non-drinkers	114,528	5640	5.50	1 (reference)	<0.001	1 (reference)	<0.001
Mild-to-moderate drinkers	207,254	8781	4.73	0.89 (0.86–0.92)		0.96 (0.92–0.99)
Heavy drinkers	77,547	4816	6.90	1.12 (1.08–1.16)		1.06 (1.02–1.10)
Per 1 alcohol unit/day increment				1.02 (1.02–1.03)	<0.001	1.01 (1.01–1.02)	<0.001
Genetic predisposition to alcohol metabolism
Low tertile	133,054	6259	5.26	1 (reference)	0.837	1 (reference)	0.388
Middle tertile	132,363	6465	5.45	1.01 (0.98–1.05)		1.01 (0.97–1.04)
High tertile	133,912	6513	5.42	1.00 (0.97–1.04)		0.99 (0.96–1.03)
Per 1 SD increment in PRS				1.01 (1.00–1.02)	0.221	1.00 (0.99–1.02)	0.551

Follow-up duration was presented as person-years. Incidence rates were presented as per 1000 person-years
CI Confidence interval, HR Hazard ratio, PRS Polygenic risk score, SD Standard deviation
^aAdjusted for age, sex, previous history of hypertension, diabetes mellitus, myocardial infarction, dyslipidemia, chronic kidney disease, heart failure, stroke, and PRS tertile for alcohol metabolism or alcohol consumption habit, respectively

ISSN: 1741-7015