Fig. 5

Predicted and altered cell–cell interactions in ARVC patient hearts. A Net plot showing the interaction number and weight among the 12 major cell clusters. Each dot indicates one cell cluster and its size is proportional to the number of cells in the cluster. The thickness of the lines connecting cell clusters indicates the differential interaction number (blue line indicates an increase in NC_RV, red line indicates an increase in AC_RV). B Differential number of the cellular interactions between NC_RV and the AC_RV. Red and blue represent enrichment in the AC_RV and NC_RV, respectively. C Circos plots showing the inferred intercellular communication network among the major cell types. D Bubble plot showing the selected ligand–receptor interactions between the 12 major cell types (ligand) and fibroblasts. ARVC, arrhythmogenic right ventricular cardiomyopathy; NC, normal control; AC_LV, left ventricle of ARVC; AC_RV, right ventricle of ARVC; NC_LV, left ventricle of NC; NC_RV, right ventricle of NC; AC_PBMC, PBMC of ARVC; PBMC, peripheral blood mononuclear cell; NK, natural killer; NP, neutrophils; VSMC, vascular smooth muscle cell