Fig. 6

Pharmacological inhibition of proinflammatory macrophages significantly alleviate the right ventricular dysfunction in a ARVC mouse model. A Experimental protocol. B Survival curve. C Representative short-axis M-mode Echo from PBS-infused wild type and Dsg2^mut/mut mice, and MCC950-infused Dsg2^mut/mut mice at 12 weeks of age. D Echo of PBS-infused wild type and Dsg2^mut/mut mice, and MCC950-infused Dsg2^mut/mut mice at 12 weeks of age. E, F Representative signal-averaged electrocardiograms (E) and electrocardiogram parameters (F) of PBS-infused wild type and Dsg2^mut/mut mice, and MCC950-infused Dsg2^mut/mut mice at 12 weeks of age. G, H Representative gross pathology (G) and long-axis sections of the hearts stained with H&E-stained (H) micrographs from PBS-infused wild type and Dsg2^mut/mut mice, and MCC950-infused Dsg2^mut/mut mice at 12 weeks of age. Scale bar, 1000 µm. I Multiple labeling staining for CCL3⁺ CD68⁺ macrophages; scale bar indicates 100 μm. Each spot represents one sample. Data are mean ± SD. The Mann–Whitney U test was performed to compare the cellular ratio of CCL3⁺ CD68⁺ macrophages.TL, tibial length; LVIDs, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole; P-Amp, P-wave amplitude; R-Amp, R-wave amplitude; Q-Amp, Q-wave amplitude; S-Amp, S-wave amplitude