OS, HR (95% CI) | OS with additional adjustment for second primary tumorsd, HR (95% CI) | DRFS, HR (95% CI) | Second primary tumorse, sHR (95% CI) | |
---|---|---|---|---|
Univariable | ||||
BRCA1-non-alteration | 1.00 (referent) | NA | 1.00 (referent) | 1.00 (referent) |
gBRCA1m 0–3 yearsa | 0.73 (0.36–1.47) | NA | 1.29 (0.79–2.11) | 4.00 (2.34–6.86) |
gBRCA1m 4–15 yearsa | 2.00 (1.15–3.47) | NA | ||
sBRCA1m | 1.17 (0.51–2.67) | NA | 1.52 (0.67–3.44) | 0.49 (0.07–3.41) |
Tumor BRCA1-PM | 0.72 (0.45–1.15) | NA | 0.77 (0.47–1.27) | 0.46 (0.21–1.02) |
Multivariableb | ||||
BRCA1-non-alteration | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) |
gBRCA1m 0–3 yearsa | 0.75 (0.36–1.53) | 0.60 (0.29–1.27) | 1.34 (0.78–2.28) | 4.04 (2.29–7.13) |
gBRCA1m 4–15 yearsa | 2.11 (1.18–3.75) | 1.43 (0.77–2.66) | ||
sBRCA1m | 0.96 (0.42–2.21) | 1.02 (0.44–2.38) | 1.30 (0.55–3.06) | 0.49 (0.07–3.47) |
Tumor BRCA1-PM | 1.19 (0.65–2.16) | 1.25 (0.68–2.28) | 0.88 (0.51–1.51) | 0.42 (0.19–0.95) |
sTILs (every 10% increment) | 0.84 (0.78–0.90) | 0.82 (0.76–0.89) | 0.74 (0.68–0.80) | 1.11 (1.03–1.19) |
sTILs by tumor BRCA1-PM statusc | 0.82 (0.68–0.98) | 0.83 (0.69–1.00) | NA | NA |