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Table 2 Hazard ratios (HRs) with 95% confidence intervals (CIs) for the associations between childhood maltreatment and any endocrine disease

From: Childhood maltreatment and risk of endocrine diseases: an exploration of mediating pathways using sequential mediation analysis

 

Number of cases (incidence rate, per 1000 person years)

Model 1a

Model 2b

Model 3c

Model 4d

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Cumulative number of experienced childhood maltreatment (as continuous variable)

 

20,885 (4.47)

1.12 (1.11–1.13)

1.12 (1.11–1.13)

1.11 (1.09–1.12)

1.10 (1.09–1.12)

Different levels of experienced childhood maltreatment (as ordinal variable)

 0

10,394 (4.12)

Ref

Ref

Ref

Ref

 1

5312 (4.44)

1.09 (1.05–1.12)

1.08 (1.05–1.12)

1.07 (1.04–1.11)

1.07 (1.04–1.11)

 ≥ 2

5179 (5.45)

1.34 (1.30–1.39)

1.34 (1.29–1.38)

1.30 (1.26–1.34)

1.29 (1.25–1.33)

Different levels of experienced childhood maltreatment (as binary variable)

 < 2

15,706 (4.22)

Ref

Ref

Ref

Ref

 ≥ 2

5179 (5.45)

1.31 (1.27–1.35)

1.30 (1.26–1.34)

1.27 (1.23–1.31)

1.26 (1.22–1.30)

Different types of experienced childhood maltreatment

 Physical abuse

  No

16,585 (4.34)

Ref

Ref

Ref

Ref

  Yes

4300 (5.02)

1.23 (1.19–1.27)

1.23 (1.19–1.27)

1.20 (1.16–1.24)

1.19 (1.15–1.23)

 Emotional abuse

  No

17,185 (4.32)

Ref

Ref

Ref

Ref

  Yes

3700 (5.32)

1.25 (1.21–1.30)

1.25 (1.20–1.29)

1.22 (1.18–1.27)

1.21 (1.17–1.26)

 Sexual abuse

  No

18,649 (4.36)

Ref

Ref

Ref

Ref

  Yes

2236 (5.61)

1.25 (1.19–1.30)

1.24 (1.19–1.30)

1.22 (1.17–1.27)

1.21 (1.16–1.26)

 Emotional neglect

  No

15,654 (4.28)

Ref

Ref

Ref

Ref

  Yes

5231 (5.13)

1.21 (1.17–1.25)

1.21 (1.17–1.24)

1.18 (1.14–1.21)

1.17 (1.14–1.21)

 Physical neglect

  No

16,661 (4.25)

Ref

Ref

Ref

Ref

  Yes

4224 (5.57)

1.26 (1.22–1.30)

1.26 (1.21–1.30)

1.23 (1.19–1.27)

1.23 (1.19–1.27)

  1. HRs with 95% CIs were derived from Cox models:
  2. aThe estimates were adjusted for sex and birth year
  3. bThe estimates were adjusted for sex, birth year, ethnicity, and country of birth
  4. cThe estimates were adjusted for sex, birth year, ethnicity, country of birth, number of siblings, maternal smoking, and being breastfed
  5. dThe estimates were adjusted for sex, birth year, ethnicity, country of birth, number of siblings, maternal smoking, being breastfed, and family history of diabetes