Table 2 MR results for metabolites that were significantly associated with the risk of more than one cancer type using the IVW approach

M32827

Andro steroid monosulfate (1)*

Colorectal

38

1.10 (1.07–1.13)

2.18 × 10⁻¹¹

1.09 × 10⁻⁸

1.05 (1.01–1.10)

0.03

1.06 (1.00–1.13)

0.07

1.10 (1.07–1.13)

7.28 × 10⁻⁸

Lung

22

1.20 (1.13–1.27)

3.26 × 10⁻¹⁰

1.48 × 10⁻⁷

1.25 (1.09–1.43)

4.22 × 10⁻³

1.22 (1.02–1.45)

0.04

1.20 (1.13–1.27)

3.11 × 10⁻⁶

Testicular germ cell

53

0.86 (0.80–0.91)

1.04 × 10⁻⁶

5.00 × 10⁻⁴

0.86 (0.78–0.96)

9.26 × 10⁻³

0.88 (0.77–1.00)

0.05

0.86 (0.80–0.91)

1.03 × 10⁻⁵

M52689

1-(1-Enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)*

Colorectal

32

1.11 (1.09–1.14)

2.92 × 10⁻²¹

1.46 × 10⁻¹⁸

1.12 (1.08–1.15)

1.21 × 10⁻⁷

1.12 (1.07–1.16)

1.14 × 10⁻⁵

1.11 (1.09–1.14)

9.51 × 10⁻¹¹

Lung

29

1.12 (1.08–1.16)

7.29 × 10⁻⁹

3.31 × 10⁻⁶

1.10 (1.03–1.16)

4.10 × 10⁻³

1.10 (1.03–1.17)

9.51 × 10⁻³

1.12 (1.08–1.15)

1.29 × 10⁻⁷

M33228

1-Arachidonoyl-GPC (20:4n6)*

Colorectal

26

1.09 (1.07–1.11)

1.95 × 10⁻¹⁵

9.78 × 10⁻¹³

1.10 (1.07–1.13)

7.19 × 10⁻⁷

1.09 (1.05–1.13)

4.32 × 10⁻⁵

1.09 (1.07–1.11)

4.17 × 10⁻⁹

Lung

27

1.10 (1.06–1.13)

3.49 × 10⁻⁸

1.58 × 10⁻⁵

1.08 (1.04–1.14)

1.86 × 10⁻³

1.09 (1.04–1.15)

3.11 × 10⁻³

1.10 (1.06–1.13)

7.38 × 10⁻⁶

M52462

1-Palmitoyl-2-arachidonoyl-GPC (16:0/20:4)

Colorectal

27

1.10 (1.08–1.13)

3.27 × 10⁻¹⁸

1.64 × 10⁻¹⁵

1.10 (1.07–1.13)

3.26 × 10⁻⁷

1.10 (1.06–1.14)

5.62 × 10⁻⁵

1.10 (1.08–1.13)

3.53 × 10⁻⁹

Lung

27

1.10 (1.07–1.14)

5.56 × 10⁻⁸

2.52 × 10⁻⁵

1.09 (1.05–1.14)

2.76 × 10⁻⁴

1.10 (1.03–1.17)

6.29 × 10⁻³

1.10 (1.07–1.14)

1.08 × 10⁻⁵

M42450

1-Stearoyl-2-arachidonoyl-GPC (18:0/20:4)

Colorectal

25

1.09 (1.07–1.11)

6.62 × 10⁻¹⁹

3.32 × 10⁻¹⁶

1.09 (1.06–1.12)

1.05 × 10⁻⁶

1.08 (1.05–1.12)

8.22 × 10⁻⁵

1.09 (1.07–1.11)

4.29 × 10⁻⁹

Lung

25

1.09 (1.06–1.13)

1.52 × 10⁻⁸

6.91 × 10⁻⁶

1.08 (1.04–1.13)

8.84 × 10⁻⁴

1.07 (1.02–1.13)

0.01

1.09 (1.06–1.13)

6.71 × 10⁻⁶

M52719

Phosphatidylcholine (16:0/22:5n3, 18:1/20:4)*

Colorectal

21

1.14 (1.10–1.17)

1.03 × 10⁻¹⁷

5.16 × 10⁻¹⁵

1.15 (1.10–1.19)

1.24 × 10⁻⁶

1.16 (1.10–1.22)

2.40 × 10⁻⁵

1.14 (1.10–1.17)

3.96 × 10⁻⁸

Lung

23

1.10 (1.06–1.16)

1.25 × 10⁻⁵

5.66 × 10⁻³

1.11 (1.04–1.18)

3.61 × 10⁻³

1.13 (1.05–1.23)

6.44 × 10⁻³

1.10 (1.06–1.15)

2.11 × 10⁻⁴

M52698

1-Adrenoyl-GPC (22:4)*

Colorectal

9

1.20 (1.14–1.27)

6.02 × 10⁻¹¹

3.01 × 10⁻⁸

1.25 (1.17–1.34)

2.01 × 10⁻⁴

1.30 (1.16–1.44)

2.14 × 10⁻³

1.20 (1.14–1.27)

1.80 × 10⁻⁴

Lung

9

1.17 (1.08–1.27)

6.76 × 10⁻⁵

0.03

1.17 (1.05–1.29)

0.02

1.21 (0.99–1.48)

0.10

1.17 (1.09–1.27)

3.99 × 10⁻³

M46111

O-methylcatechol sulfate

Colorectal

9

1.41 (1.31–1.52)

6.25 × 10⁻¹⁹

3.13 × 10⁻¹⁶

1.49 (1.25–1.78)

2.35 × 10⁻³

1.87 (1.34–2.62)

8.21 × 10⁻³

1.41 (1.31–1.51)

1.18 × 10⁻⁵

Lung

4

2.81 (2.33–3.37)

4.32 × 10⁻²⁸

1.96 × 10⁻²⁵

2.85 (2.04–4.00)

8.86 × 10⁻³

4.03 (1.35–12.06)

0.13

2.81 (2.48–3.17)

4.82 × 10⁻⁴

M34397

1-Arachidonylglycerol (20:4)

Colorectal

6

1.18 (1.13–1.24)

9.69 × 10⁻¹³

4.86 × 10⁻¹⁰

1.20 (1.14–1.27)

1.50 × 10⁻³

1.28 (1.13–1.45)

0.02

1.18 (1.13–1.23)

4.19 × 10⁻⁴

Lung

8

1.19 (1.11–1.27)

7.87 × 10⁻⁷

3.57 × 10⁻⁴

1.14 (1.05–1.24)

0.02

1.07 (0.93–1.23)

0.40

1.19 (1.13–1.25)

4.07 × 10⁻⁴

M35157

N6-carbamoylthreonyladenosine

Colorectal

6

1.34 (1.21–1.49)

1.83 × 10⁻⁸

9.19 × 10⁻⁶

1.24 (1.00–1.54)

0.11

1.97 (1.19–3.27)

0.06

1.34 (1.22–1.48)

1.65 × 10⁻³

Lung

5

1.71 (1.47–2.00)

1.38 × 10⁻¹¹

6.28 × 10⁻⁹

1.61 (1.23–2.12)

0.03

2.77 (1.36–5.66)

0.07

1.71 (1.48–1.99)

2.11 × 10⁻³

Breast

7

0.75 (0.68–0.82)

3.81 × 10⁻⁹

1.82 × 10⁻⁶

0.84 (0.73–0.97)

0.05

0.65 (0.41–1.03)

0.13

0.75 (0.68–0.82)

1.06 × 10⁻³

M46455

X-21410

Colorectal

45

1.13 (1.10–1.16)

3.61 × 10⁻¹⁹

1.81 × 10⁻¹⁶

1.15 (1.08–1.24)

1.97 × 10⁻⁴

1.19 (1.12–1.26)

3.15 × 10⁻⁶

1.13 (1.10–1.16)

1.83 × 10⁻¹¹

Lung

25

1.29 (1.22–1.35)

7.06 × 10⁻²³

3.21 × 10⁻²⁰

1.24 (1.14–1.35)

3.79 × 10⁻⁵

1.17 (1.05–1.30)

0.01

1.29 (1.22–1.35)

6.64 × 10⁻¹⁰

Breast

45

0.93 (0.91–0.94)

5.24 × 10⁻¹⁴

2.50 × 10⁻¹¹

0.93 (0.90–0.97)

2.44 × 10⁻³

0.94 (0.90–0.99)

0.01

0.93 (0.91–0.94)

1.95 × 10⁻⁹

Prostate

46

0.91 (0.89–0.93)

5.48 × 10⁻¹²

2.70 × 10⁻⁹

0.89 (0.84–0.95)

6.35 × 10⁻⁴

0.88 (0.83–0.94)

3.37 × 10⁻⁴

0.91 (0.89–0.93)

1.47 × 10⁻⁸

Renal cell

46

0.85 (0.81–0.90)

1.19 × 10⁻⁹

5.66 × 10⁻⁷

0.94 (0.85–1.04)

0.24

0.89 (0.80–0.99)

0.04

0.85 (0.81–0.90)

1.62 × 10⁻⁷

M36098

4-Vinylphenol sulfate

Prostate

8

0.68 (0.61–0.76)

9.77 × 10⁻¹³

4.81 × 10⁻¹⁰

0.74 (0.62–0.90)

0.02

0.52 (0.31–0.88)

0.05

0.68 (0.61–0.76)

1.88 × 10⁻⁴

Renal cell

8

0.49 (0.40–0.61)

1.77 × 10⁻¹¹

8.43 × 10⁻⁹

0.41 (0.24–0.71)

0.01

0.38 (0.04–3.57)

0.43

0.49 (0.41–0.59)

1.28 × 10⁻⁴

M37181

4-Allylphenol sulfate

Prostate

8

0.68 (0.63–0.74)

9.30 × 10⁻¹⁹

4.58 × 10⁻¹⁶

0.64 (0.52–0.79)

4.39 × 10⁻³

0.88 (0.55–1.39)

0.60

0.68 (0.63–0.74)

4.78 × 10⁻⁵

Renal cell

9

0.54 (0.45–0.64)

8.33 × 10⁻¹³

3.96 × 10⁻¹⁰

0.68 (0.49–0.95)

0.05

1.35 (0.45–4.09)

0.61

0.54 (0.45–0.64)

9.66 × 10⁻⁵

Colorectal

5

1.32 (1.18–1.48)

2.11 × 10⁻⁶

1.06 × 10⁻³

1.41 (1.15–1.73)

0.03

1.13 (0.49–2.61)

0.80

1.32 (1.21–1.44)

3.56 × 10⁻³

M46356

X-21312

Prostate

25

0.85 (0.82–0.89)

3.84 × 10⁻¹⁵

1.89 × 10⁻¹²

0.91 (0.85–0.97)

0.01

0.79 (0.71–0.88)

3.23 × 10⁻⁴

0.85 (0.82–0.89)

4.31 × 10⁻⁸

Renal cell

27

0.67 (0.62–0.72)

4.00 × 10⁻²³

1.90 × 10⁻²⁰

0.63 (0.52–0.77)

1.33 × 10⁻⁴

0.57 (0.42–0.75)

6.79 × 10⁻⁴

0.67 (0.62–0.72)

1.18 × 10⁻¹¹

Breast

24

0.86 (0.83–0.88)

5.71 × 10⁻²⁵

2.72 × 10⁻²²

0.90 (0.83–0.98)

0.03

0.82 (0.73–0.92)

2.17 × 10⁻³

0.86 (0.83–0.88)

4.20 × 10⁻¹⁰

M38168

16a-Hydroxy DHEA 3-sulfate

Colorectal

30

1.06 (1.03–1.08)

6.26 × 10⁻⁵

0.03

1.05 (1.01–1.09)

0.03

1.04 (0.98–1.10)

0.19

1.06 (1.03–1.08)

1.01 × 10⁻⁴

Testicular germ cell

42

0.88 (0.82–0.94)

7.00 × 10⁻⁵

0.03

0.89 (0.82–0.97)

0.01

0.88 (0.79–0.98)

0.02

0.88 (0.82–0.94)

2.78 × 10⁻⁴

M27719

Galactonate

Colorectal

5

0.81 (0.76–0.87)

3.67 × 10⁻⁹

1.84 × 10⁻⁶

0.81 (0.73–0.90)

0.02

0.82 (0.64–1.04)

0.19

0.81 (0.78–0.85)

4.64 × 10⁻⁴

Testicular germ cell

5

0.64 (0.52–0.78)

9.60 × 10⁻⁶

4.62 × 10⁻³

0.66 (0.49–0.88)

0.05

0.93 (0.46–1.86)

0.84

0.64 (0.57–0.71)

1.52 × 10⁻³

M52449

1-Stearoyl-2-arachidonoyl-GPI (18:0/20:4)

Breast

22

1.06 (1.03–1.08)

8.31 × 10⁻⁵

0.04

1.09 (1.03–1.15)

4.44 × 10⁻³

1.05 (0.99–1.12)

0.13

1.06 (1.03–1.08)

5.25 × 10⁻⁴

Colorectal

22

1.09 (1.05–1.13)

2.27 × 10⁻⁵

0.01

1.06 (1.00–1.12)

0.06

1.07 (0.97–1.18)

0.20

1.09 (1.05–1.13)

3.69 × 10⁻⁴

M36099

4-Ethylphenylsulfate

Colorectal

8

1.42 (1.30–1.55)

5.07 × 10⁻¹⁴

2.54 × 10⁻¹¹

1.50 (1.26–1.79)

2.66 × 10⁻³

1.52 (1.00–2.31)

0.10

1.42 (1.30–1.55)

1.34 × 10⁻⁴

Prostate

8

0.69 (0.63–0.75)

9.05 × 10⁻¹⁶

4.45 × 10⁻¹³

0.65 (0.54–0.77)

1.91 × 10⁻³

0.76 (0.45–1.27)

0.34

0.69 (0.63–0.75)

8.83 × 10⁻⁵

M46294

X-21285

Breast

24

0.92 (0.89–0.95)

1.95 × 10⁻⁷

9.30 × 10⁻⁵

0.86 (0.77–0.96)

0.01

0.95 (0.82–1.11)

0.55

0.92 (0.89–0.95)

2.82 × 10⁻⁵

Colorectal

25

1.12 (1.08–1.16)

8.72 × 10⁻¹⁰

4.37 × 10⁻⁷

1.16 (1.06–1.26)

2.40 × 10⁻³

1.20 (1.07–1.34)

4.08 × 10⁻³

1.12 (1.08–1.16)

2.47 × 10⁻⁶

M46590

X-07765

Lung

4

1.47 (1.25–1.73)

3.41 × 10⁻⁶

1.55 × 10⁻³

1.36 (1.15–1.61)

0.04

1.55 (0.84–2.86)

0.30

1.47 (1.25–1.73)

0.02

Prostate

8

0.81 (0.75–0.87)

6.92 × 10⁻⁸

3.41 × 10⁻⁵

0.85 (0.78–0.93)

0.01

0.73 (0.56–0.95)

0.06

0.81 (0.75–0.87)

1.02 × 10⁻³

M46710

X-17690

Breast

6

0.86 (0.80–0.92)

1.06 × 10⁻⁵

5.06 × 10⁻³

0.89 (0.79–0.99)

0.08

0.88 (0.58–1.31)

0.56

0.86 (0.80–0.92)

6.99 × 10⁻³

Prostate

9

0.79 (0.73–0.86)

1.69 × 10⁻⁸

8.33 × 10⁻⁶

0.85 (0.78–0.93)

6.11 × 10⁻³

0.91 (0.64–1.27)

0.59

0.79 (0.73–0.86)

4.87 × 10⁻⁴