Table 4 Performance of EL-NDI and RF in external validation cohort (n = 1347)
BSIDIII cognitive score < 85 at 24 months CA | ||||
EL-NDI Coarse-to-fine features selection | RF All-features-in | |||
Cognitive (CDelay) | Motor (MDelay) | Cognitive (CDelay) | Motor (MDelay) | |
Variables | 10 | 4 | 83 | 83 |
Accuracy | 75.1% | 79.1% | 73.2% | 75.7% |
AUC | 0.78 | 0.82 | 0.78 | 0.82 |
95% CIs | 0.75–0.82 | 0.79–0.85 | 0.73–0.80 | 0.79–0.85 |
MCC | 0.321 | 0.425 | 0.310 | 0.415 |
Sensitivity | 62.0% | 64.7% | 64.5% | 71.6% |
Specificity | 77.5% | 82.3% | 74.8% | 76.8% |
PPV | 34.5% | 48.4% | 32.6% | 44.2% |
NPV | 91.4% | 90.1% | 91.8% | 91.3% |
LR +  | 2.75 | 3.65 | 2.56 | 3.08 |
LR −  | 0.47 | 0.48 | 0.47 | 0.37 |
BSIDIII motor score declines≧ 15 between 6 and 24 months CA | ||||
Cognitive (CRegres) | Motor (MRegres) | Cognitive (CRegres) | Motor (MRegres) | |
4 | 4 | 75 | 75 | |
Accuracy | 69.6% | 72.2% | 61.6% | 75.6% |
AUC | 0.76 | 0.79 | 0.68 | 0.76 |
95% CIs | 0.74–0.78 | 0.78–0.80 | 0.64–0.71 | 0.73–0.79 |
MCC | 0.348 | 0.397 | 0.240 | 0.403 |
Sensitivity | 68.9% | 76.0% | 67.9% | 68.4% |
Specificity | 69.9% | 71.2% | 59.4% | 77.5% |
PPV | 44.6% | 41.8% | 36.9% | 45.3% |
NPV | 86.5% | 91.6% | 84.1% | 90.0% |
LR +  | 2.29 | 2.64 | 1.67 | 3.04 |
LR −  | 0.44 | 0.40 | 0.54 | 0.41 |