Table 1 Demographic characteristics of the study population, exposed women, and matched unexposed women presented by drug preparation and route of administration

Person time (in years)

9438

47,183

3100

15,505

8341

41,693

9272

46,356

922

4612

Age (years),

mean (SD)

71.4 (11.2)

71.4 (11.2)

58.2 (6.5)

58.2 (6.5)

57.2 (4.8)

57.2 (4.8)

55.8 (4.9)

55.8 (4.9)

59.8 (6.0)

59.8 (6.0)

Median, [Q1–Q3]

71.0 (62.0–79.0)

71.0 (62.0–79.0)

56.0 (54.0–59.0)

56.0 (54.0–59.0)

56.0 (54.0–58.0)

56.0 (54.0–58.0)

54.0 (53.0–56.0)

54.0 (53.0–56.0)

58.0 (56.0–62.0)

58.0 (56.0–62.0)

Age group (years)

n (%)

 53–62

2577 (25.8)

12885 (25.8)

2715 (85.1)

13,576 (85.1)

7508 (89.9)

37,535 (89.9)

8803 (94.4)

44,016 (94.4)

699 (75.7)

3495 (75.7)

 63–72

2976 (29.8)

14,880 (29.8)

308 (9.7)

1540 (9.7)

654 (7.8)

3270 (7.8)

316 (3.4)

1580 (3.4)

175 (19.0)

875 (19.0)

  > 73

4428 (44.4)

22,124 (44.3)

166 (5.2)

830 (5.2)

190 (2.3)

950 (2.3)

204 (2.2)

1020 (2.2)

49 (5.3)

245 (5.3)

Education (years),

n (%)

  < 9

1321 (13.2)

6624 (13.3)

55 (1.7)

361 (2.3)

46 (0.6)

707 (1.7)

75 (0.8)

785 (1.7)

9 (1.0)

97 (2.1)

 9

824 (8.3)

3836 (7.7)

158 (5.0)

984 (6.2)

439 (5.3)

2681 (6.4)

391 (4.2)

2853 (6.1)

59 (6.4)

313 (6.8)

 10–12

4228 (42.4)

21,659 (43.4)

1356 (42.5)

7739 (48.5)

3931 (47.1)

20,584 (49.3)

4448 (47.7)

23,230 (49.8)

434 (47.0)

2176 (47.29

 12 + 

3525 (35.3)

17,147 (34.3)

1607 (50.4)

6788 (42.6)

3925 (47.0)

17,637 (42.2)

4379 (47.0)

19,566 (42.0)

421 (45.6)

2001 (43.4)

 Unknown

83 (0.8)

623 (1.2)

13 (0.4)

74 (0.5)

11 (0.1)

146 (0.3)

30 (0.3)

182 (0.4)

0 (0.0)

28 (0.6)

Civil status,

n (%)

 Married/registered partner

4481 (44.9)

22,350 (44.8)

1429 (44.8)

7144 (44.8)

3742 (44.8)

18,748 (44.9)

4177 (44.8)

20,931 (44.9)

413 (44.7)

2072 (44.9)

Income,

n (%)

 Low

4931 (49.4)

24,396 (48.9)

3189 (49.2)

15,946 (49.7)

4109 (49.2)

20,669 (49.5)

9323 (49.3)

46,616 (49.4)

923 (49.3)

2280 (49.4)

 Middle

2337 (47.4)

11,564 (47.4)

1569 (47.3)

7925 (46.9)

1935 (47.1)

9756 (47.2)

4596 (47.1)

23,028 (47.0)

455 (46.9)

1074 (47.1)

 High

75 (3.2)

428 (3.7)

742 (3.5)

3717 (3.4)

72 (3.7)

322 (3.3)

2165 (3.6)

10,823 (3.6)

213 (3.8)

38 (3.5)

Obesity, n (%)

155 (1.6)

721 (1.4)

41 (1.3)

342 (2.1)

96 (1.1)

839 (2.0)

246 (2.6)

1011 (2.2)

5 (0.5)

80 (1.7)

Alcohol dependence, n (%)

46 (0.5)

116 (0.2)

17 (0.5)

56 (0.4)

25 (0.3)

162 (0.4)

47 (0.5)

209 (0.4)

5 (0.5)

22 (0.5)

Charlson Comorbidity Index

n (%)

 0

8773 (87.9)

43,952 (88.1)

2813 (88.2)

14,001 (87.8)

7358 (88.1)

37,037 (88.7)

8270 (88.7)

41,115 (88.2)

810 (87.8)

4061 (88.0)

 1

1198 (12.0)

5887 (11.8)

348 (10.9)

1770 (11.1)

986 (11.8)

4677 (11.2)

1044 (11.2)

5454 (11.7)

113 (12.2)

554 (11.9)

 2 + 

10 (0.1)

50 (0.1)

29 (0.9)

175 (1.1)

8 (0.1)

42 (0.1)

9 (0.1)

47 (0.1)

0 (0.0)

0 (0.0)