Table 6 Crude and adjusted Cox regression models stratified by age regarding the association of sex steroid treatment with laboratory confirmed SARS-CoV-2 infection or outpatient visits/ inpatient hospitalizations with or without the need for ICU admission due to COVID-19
Laboratory confirmed SARS-CoV-2 | Outpatient visits/Inpatient hospitalizations with/without ICU admission | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Exposed | Unexposed | Exposed | Unexposed | ||||||||||
Exposure | Age | n total | n events (%) | n total | n events (%) | Crude HR (95% CI) | Adjusted HR (95% CI) | n total | n events (%) | n total | n events (%) | Crude HR (95% CI) | Adjusted HR (95% CI) |
Local estrogens alone | 53–62 | 2577 | 443 (4.43) | 12,885 | 2077 (4.16) | 1.05 (0.93–1.18) | 1.07 (0.95–1.20) | 2577 | 68 (0.68) | 12,885 | 353 (0.71) | 1.13 (0.67–1.92) | 1.13 (0.67–1.92) |
63–72 | 2976 | 271 (2.71) | 14,880 | 1158 (2.32) | 1.18 (1.01–1.37) | 1.17 (1.00–1.36) | 2976 | 97 (0.97) | 14,880 | 311 (0.62) | 2.21 (1.41–3.48) | 2.21 (1.41–3.48) | |
> 73 | 4428 | 330 (3.30) | 22,124 | 1316 (2.64) | 1.25 (1.09–1.43) | 1.19 (1.04–1.37) | 4428 | 219 (2.19) | 22,124 | 858 (1.72) | 1.60 (1.18–2.19) | 1.60 (1.18–2.19) | |
Systemic estrogens without progestogens | 53–62 | 2715 | 392 (12.3) | 13,576 | 2076 (13.02) | 0.93 (0.83–1.04) | 0.94 (0.84–1.06) | 2715 | 64 (2.00) | 13,576 | 300 (1.88) | 0.92 (0.55–1.54) | 0.92 (0.55–1.54) |
63–72 | 308 | 20 (0.64) | 1540 | 100 (0.62) | 0.99 (0.60–1.64) | 1.01 (0.61–1.69) | 308 | 3 (0.09) | 1540 | 30 (0.19) | NE | NE | |
> 73 | 166 | 11 (0.35) | 830 | 35 (0.22) | 1.47 (0.73–2.98) | 1.38 (0.67–2.82) | 166 | 6 (0.17) | 830 | 19 (0.12) | 0.83 (0.10–6.92) | 0.83 (0.10–6.92) | |
Systemic estrogens and progestogens | 53–62 | 7508 | 1141 (13.66) | 37,535 | 5360 (12.84) | 1.08 (1.01–1.15) | 1.07 (1.00–1.15) | 7508 | 111 (1.33) | 37,535 | 691 (1.65) | 0.72 (0.51–1.03) | 0.72 (0.51–1.03) |
63–72 | 654 | 47 (0.57) | 3270 | 223 (0.54) | 1.08 (0.78–1.49) | 1.11 (0.80–1.54) | 654 | 12 (0.14) | 3270 | 57 (0.14) | 1.14 (0.43–3.00) | 1.14 (0.43–3.00) | |
> 73 | 190 | 8 (0.09) | 950 | 31 (0.08) | 1.17 (0.51–2.66) | 1.18 (0.51–2.71) | 190 | 0 (0.00) | 950 | 28 (0.07) | NE | NE | |
Progestogens alone | 53–62 | 8803 | 1344 (14.41) | 44,016 | 6440 (13.81) | 1.04 (0.98–1.11) | 1.03 (0.97–1.10) | 8803 | 154 (1.65) | 44,016 | 867 (1.86) | 0.74 (0.54–1.01) | 0.74 (0.54–1.01) |
63–72 | 316 | 15 (0.16) | 1580 | 108 (0.23) | 0.70 (0.40–1.23) | 0.68 (0.38–1.23) | 316 | 0 (0.00) | 1580 | 13 (0.03) | NE | NE | |
> 73 | 204 | 14 (0.15) | 1020 | 53 (0.11) | 1.43 (0.79–2.59) | 1.48 (0.77–2.84) | 204 | 14 (0.16) | 1020 | 32 (0.07) | 2.50 (0.75–8.30) | 2.50 (0.75–8.30) | |
Tibolone alone | 53–62 | 699 | 119 (12.90) | 3495 | 509 (11.03) | 1.20 (0.97–1.47) | 1.19 (0.97–1.47) | 699 | 17 (1.87) | 3495 | 80 (1.73) | 0.77 (0.27–2.21) | 0.77 (0.27–2.21) |
63–72 | 175 | 24 (2.58) | 875 | 72 (1.56) | 1.80 (1.12–2.89) | 1.82 (1.12–2.95) | 175 | 3 (0.31) | 875 | 9 (0.19) | 1.25 (0.14–11.18) | 1.25 (0.14–11.18) | |
> 73 | 49 | 1 (0.12) | 245 | 8 (0.17) | 0.63 (0.08–5.00) | 0.70 (0.09–5.72) | 49 | 3 (0.31) | 245 | 6 (0.12) | 2.50 (0.23–27.57) | 2.50 (0.23–27.57) | |