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Fig. 4 | BMC Medicine

Fig. 4

From: TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro

Fig. 4

The cGAS-STING pathway activation induced by MSA-2 is suppressed by R788 and AMX. A The schematics of signaling interactions between R788/AMX and the cGAS-STING pathway. B–C CCK-8 assay showed the cytotoxicities of R788 and AMX with increased dosages. D Western blotting analysis of p-p65, p-IRF3, and p-TBK1 from THP-1 cells subjected to MSA-2 stimulation and treated with R788 (10–20 μM) or AMX (100–200 μM). The qualification of p-TBK1 (E) and p-p65 (F) when normalized with β-actin. G–L RT-qPCR showed the relative levels (normalized with GAPDH) of IFNB, TNFA, and IL6 from THP-1 cells treated with R788 (10 μM) or AMX (200 μM)

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BMC Medicine

ISSN: 1741-7015

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