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Fig. 5 | BMC Medicine

Fig. 5

From: TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro

Fig. 5

R788 and AMX suppressed cGAS/STING-dependent pro-inflammatory signaling induced by TDP-43/SOD1. A Western blotting analyzed the levels of transiently transfected ALS toxic proteins and p-TBK1 in NSC-34 cells. B WB analysis of p-TBK1, p-p65, and p-IRF3 in doxycycline-inducible TDP43/Q331K NSC-34 cells. C–H RT-qPCR showed the relative levels (normalized with GAPDH) of IFNB, TNFA, and IL6 from NSC-34 cells treated with R788 (10 μM) or AMX (200 μM)

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BMC Medicine

ISSN: 1741-7015

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