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Table 2 Odds ratio for ARHL associated with genetic risk group

From: Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss

    

Model 1

 

Model 2

 

Model 3

 

Model 4

 

Genetic risk

Total no. of participants

No. of ARHL cases

Prevalence (%)

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Low

75,322

15,453

20.52

1 (reference)

1 (reference)

1 (reference)

1 (reference)

Intermediate

225,879

52,060

23.05

1.16 (1.14–1.19)

 < .001

1.15 (1.12–1.17)

 < .001

1.14 (1.12–1.17)

 < .001

1.14 (1.11–1.17)

 < .001

High

71,499

18,477

25.84

1.36 (1.33–1.40)

 < .001

1.35 (1.32–1.39)

 < .001

1.34 (1.31–1.38)

 < .001

1.34 (1.31–1.39)

 < .001

Very high

3764

1076

28.59

1.58 (1.47–1.70)

 < .001

1.55 (1.43–1.68)

 < .001

1.49 (1.36–1.63)

 < .001

1.49 (1.36–1.62)

 < .001

perSD increase

   

1.12 (1.11–1.13)

 < .001

1.12 (1.11–1.13)

 < .001

1.12 (1.11–1.13)

 < .001

1.12 (1.11–1.13)

 < .001

  1. Model 1 was adjusted by age, sex, genotype array, and PC 1 to 10
  2. Model 2: Model 1 + education years + household income + Townsend deprivation index + number in household
  3. Model 3: Model 2 + body mass index + height + weight + waist circumference + systolic blood pressure + diastolic blood pressure + Total cholesterol + HDL cholesterol + LDL cholesterol + Triglycerides + Creatinine + eGFR + Fasting blood glucose + HbA1c
  4. Model 4: Model 3 + tinnitus + major chronic comorbidities (hypercholesterolemia, hypertension, heart failure, chronic kidney disease, any stroke, diabetic hypoglycemia, type 2 diabetes mellitus, and coronary artery disease)
  5. Abbreviations: ARHL age-related hearing loss, SD standard deviation, OR odds ratio, CI confidence interval, PC principal component
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BMC Medicine

ISSN: 1741-7015

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