Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss

Table 3 Odds ratio for ARHL associated with composite healthy lifestyle score

				Model 1		Model 2		Model 3		Model 4
Lifestyle	Total no. of participants	No. of ARHL cases	Prevalence (%)	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
Very poor	3496	1303	37.27	1 (reference)		1 (reference)		1 (reference)		1 (reference)
Poor	26,609	7652	28.76	0.69 (0.64–0.75)	< .001	0.70 (0.65–0.76)	< .001	0.68 (0.62–0.75)	< .001	0.74 (0.67–0.82)	< .001
Intermediate	49,094	10,064	20.50	0.48 (0.44–0.51)	< .001	0.48 (0.44–0.52)	< .001	0.46 (0.42–0.50)	< .001	0.53 (0.48–0.59)	< .001
Ideal	6389	936	14.65	0.33 (0.30–0.36)	< .001	0.32 (0.29–0.36)	< .001	0.30 (0.27–0.34)	< .001	0.38 (0.33–0.43)	< .001

Detailed information on the definition of the composite healthy lifestyle score is shown in Additional file 1: Method S7
Model 1 was adjusted by age, sex, genotype array, and PC 1 to 10
Model 2: Model 1 + education years + household income + Townsend deprivation index + number in household
Model 3: Model 2 + body mass index + height + weight + waist circumference + systolic blood pressure + diastolic blood pressure + Total cholesterol + HDL cholesterol + LDL cholesterol + Triglycerides + Creatinine + eGFR + Fasting blood glucose + HbA1c
Model 4: Model 3 + tinnitus + major chronic comorbidities (hypercholesterolemia, hypertension, heart failure, chronic kidney disease, any stroke, diabetic hypoglycemia, type 2 diabetes mellitus, and coronary artery disease)
Abbreviations: ARHL age-related hearing loss, SD standard deviation, OR odds ratio, CI confidence interval, PC principal component

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