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Table 2 Logistic regression for treatment prescription according to latent classes

From: Patterns of comorbidities in patients with atrial fibrillation and impact on management and long-term prognosis: an analysis from the Prospective Global GLORIA-AF Registry

Drugs, OR [95%CI]

Low complexity class

CV risk factors class

Atherosclerotic class

Thromboembolic class

Cardiometabolic class

High complexity class

OAC

Ref.

1.36 [1.24–1.48]

1.27 [1.11–1.45]

1.48 [1.27–1.72]

1.76 [1.49–2.09]

1.57 [1.35–1.81]

NOAC (vs. VKA)

Ref.

1.21 [1.11–1.31]

1.03 [0.90–1.17]

1.20 [1.04–1.37]

1.12 [0.98–1.29]

1.18 [1.03–1.35]

ACE inhibitors

Ref.

1.15 [1.07–1.24]

1.06 [0.94–1.19]

1.13 [0.99–1.28]

0.99 [0.87–1.12]

1.02 [0.90–1.15]

Angiotensin receptor blockers

Ref.

1.13 [1.05–1.22]

0.96 [0.85–1.09]

0.86 [0.75–1.00]

1.00 [0.87–1.14]

0.97 [0.86–1.11]

Diuretics

Ref.

1.20 [1.11–1.29]

1.06 [0.94–1.20]

0.97 [0.85–1.11]

1.37 [1.20–1.56]

1.08 [0.95–1.22]

Beta-blockers

Ref.

1.23 [1.15–1.32]

1.20 [1.06–1.34]

1.16 [1.03–1.31]

1.26 [1.11–1.43]

1.27 [1.13–1.42]

Digoxin

Ref.

0.98 [0.87–1.11]

0.77 [0.64–0.93]

0.88 [0.71–1.10]

0.86 [0.70–1.04]

1.04 [0.85–1.27]

Verapamil/diltiazem

Ref.

1.00 [0.88–1.14]

1.56 [1.25–1.95]

1.18 [0.93–1.49]

1.84 [1.50–2.26]

2.43 [2.02–2.93]

Class IC antiarrhythmics

Ref.

1.03 [0.90–1.17]

0.94 [0.68–1.31]

1.00 [0.76–1.31]

0.98 [0.71–1.36]

0.93 [0.72–1.21]

Amiodarone/dronedarone

Ref.

0.97 [0.88–1.07]

0.96 [0.83–1.12]

0.93 [0.77–1.12]

0.88 [0.74–1.03]

0.88 [0.75–1.04]

Other antiarrhythmics

Ref.

0.84 [0.72–0.97]

0.84 [0.68–1.03]

0.76 [0.57–1.00]

0.85 [0.67–1.08]

1.13 [0.90–1.41]

Oral hypoglycemic agents

Ref.

1.42 [1.18–1.71]

1.24 [0.99–1.56]

1.27 [0.92–1.76]

1.41 [1.13–1.77]

1.67 [1.29–2.17]

Insulin

Ref.

0.92 [0.69–1.22]

1.09 [0.79–1.50]

0.75 [0.44–1.26]

1.43 [1.05–1.94]

0.99 [0.69–1.42]

Proton pump inhibitors

Ref.

1.20 [1.10–1.30]

1.32 [1.16–1.50]

1.55 [1.36–1.77]

1.66 [1.45–1.90]

3.72 [3.30–4.19]

Statins

Ref.

4.73 [4.38–5.11]

4.35 [3.85–4.92]

2.90 [2.55–3.29]

8.09 [7.06–9.27]

5.35 [4.73–6.06]

  1. Class IC antiarrhythmics includes propafenone and flecainide. Italic values depict results with p < 0.05
  2. ACE angiotensin converting enzyme, OAC oral anticoagulant, NOAC non-vitamin K antagonist oral anticoagulant, VKA vitamin K antagonist