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Fig. 7 | BMC Medicine

Fig. 7

From: PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer

Fig. 7

PREX-in1 sensitizes the efficacy of IR therapy in CRC mouse models. A The overall design of the animal experiments. B The representative image of MC38 and IR-resistant cell line IR-CMT93 tumors treated with IR or IR+PREX-in1. C, D The volume curve and weight of MC38 and IR-CMT93 tumors treated with IR or IR+PREX-in1. E Representative HE images and IHC images of CD3 and CD8 staining (left) and statistical analysis (right) of MC38 and IR-CMT93 tumors. Scale bar: 100 μm. F Representative flow cytometry images (left) and quantitative analysis (right) of tumor-infiltrating lymphocytes in MC38 and IR-CMT93 tumors. ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001

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BMC Medicine

ISSN: 1741-7015

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