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Table 4 Cox proportional hazards regression models for the association between proteomic sleep score and sleep duration with incident diabetes mellitus. Analyses are mutually adjusted for proteomic sleep score and sleep duration

From: Very short sleep duration reveals a proteomic fingerprint that is selectively associated with incident diabetes mellitus but not with incident coronary heart disease: a cohort study

 

Model 1

Model 2

Model 3

HR

(95% CI)

HR

95% CI

HR

95% CI

Proteomic score Q1a

1.52***

(1.28, 1.81)

1.48***

(1.24, 1.77)

1.27**

(1.06, 1.53)

Proteomic score Q5a

1.22*

(1.01, 1.48)

1.25*

(1.03, 1.52)

1.20

(0.99, 1.45)

Sleep duration Q1 (4.00–6.57 h)

1.33*

(1.02, 1.74)

1.26

(0.96, 1.66)

1.27

(0.96, 1.67)

Sleep duration Q2 (6.64–7.14 h)

1.34*

(1.01, 1.77)

1.34*

(1.01, 1.77)

1.29

(0.97, 1.71)

Sleep duration Q3 (7.21–7.57 h)

Reference

Reference

Reference

Sleep duration Q4 (7.64–8.00 h)

1.27

(0.97, 1.66)

1.26

(0.96, 1.65)

1.25

(0.95, 1.64)

Sleep duration Q5 (8.14–11.00 h)

1.46*

(1.08, 1.97)

1.42*

(1.05, 1.93)

1.42*

(1.04, 1.93)

  1. Italic values denote statistically significant results
  2. Model 1 is stratified by HbA1c concentration and adjusted for age and sex
  3. Model 2 is additionally adjusted for cystatin C, education, physical activity, smoking, alcohol consumption, shift work, and insomnia symptoms
  4. Model 3 is additionally adjusted for body mass index, waist circumference, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides
  5. aExpressed as the HR and 95% CI of the incremental increase per SD of the proteomic sleep score
  6. *p < 0.05, **p < 0.01, ***p < 0.001