Hill AB: The environment and disease: association or causation. Evolution of Epidemiologic Ideas: Annotated Readings on Concepts in Methods. Edited by: Greenland S. 1987, Chestnut Hill, MA, USA: Epidemiology Resources, Inc, 7-12.
Google Scholar
Fischl MA, Richman DD, Grieco MH, Gottlieb MS, Volberding PA, Laskin OL, Leedom JM, Groopman JE, Mildvan D, Schooley RT, et al: The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med. 1987, 317: 185-191. 10.1056/NEJM198707233170401.
Article
CAS
PubMed
Google Scholar
Volberding PA, Lagakos SW, Grimes JM, Stein DS, Balfour HH, Reichman RC, Bartlett JA, Hirsch MS, Phair JP, Mitsuyasu RT, et al: The duration of zidovudine benefit in persons with asymptomatic HIV infection: prolonged evaluation of protocol 019 of the AIDS Clinical Trials Group. JAMA. 1994, 272: 437-442. 10.1001/jama.1994.03520060037029.
Article
CAS
PubMed
Google Scholar
Concorde: MRC/ANRS randomized double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection. Lancet. 1994, 343: 871-881.
Article
Google Scholar
Volberding PA, Lagakos SW, Grimes JM, Stein DS, Rooney J, Meng TC, Fischl MA, Collier AC, Phair JP, Hirsch MS, Hardy WD, Balfour HH, Reichman RC: A comparison of immediate with deferred zidovudine therapy for asymptomatic HIV-infected adults with CD4 cell counts of 500 or more per cubic millimeter. N Engl J Med. 1995, 333: 401-407. 10.1056/NEJM199508173330701.
Article
CAS
PubMed
Google Scholar
Cao Y, Ho DD, Todd J, Kokka R, Urdea M, Lifson JD, Piatak M, Chen S, Hahn BH, Saag MS, et al: Clinical evaluation of branched DNA signal amplification for quantifying HIV type 1 in human plasma. AIDS Res Hum Retroviruses. 1995, 11: 353-361. 10.1089/aid.1995.11.353.
Article
CAS
PubMed
Google Scholar
Eron J, Benoit S, Jemsek J, Quinn J, Fallon MA, Rubin M: A randomized double-blind multicenter comparative trial of lamivudine (3TC) monotherapy vs. zidovudine (ZDV) monotherapy vs. 3TC ZDV combination in naïve patients with CD4 cell counts of 200-500/mm3. Program and abstracts of the Second National Conference on Human Retroviruses and Related Infections, Washington, D.C., February 1, 1995. 1995, Washington, D.C: American Society for Microbiology, 173-Abstract
Google Scholar
Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM: Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 1995, 373: 117-122. 10.1038/373117a0.
Article
CAS
PubMed
Google Scholar
Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 1995, 373: 123-126. 10.1038/373123a0.
Article
CAS
PubMed
Google Scholar
Ho D: Time to hit HIV, early and hard. N Engl J Med. 1995, 333: 450-451. 10.1056/NEJM199508173330710.
Article
CAS
PubMed
Google Scholar
Phillips AN, Staszewski S, Weber R, Kirk O, Francioli P, Miller V, Vernazza P, Lundgren JD, Ledergerber B, Swiss HIV Cohort Study; Frakfurt HIV Clinic Cohort; EuroSIDA Study Group: HIV viral load response to antiretroviral therapy according to the baseline CD4 cell count and viral load. JAMA. 2001, 286: 2560-2567. 10.1001/jama.286.20.2560.
Article
CAS
PubMed
Google Scholar
Cozzi Lepri A, Phillips AN, d’Arminio Monteforte A, Castelli F, Antinori A, de Luca A, Pezzotti P, Alberici F, Cargnel A, Grima P, Piscopo R, Prestileo T, Scalise G, Vigevani M, Moroni M; ICONA Study Group: When to start highly active antiretroviral therapy in chronically HIVinfected patients: evidence from the ICONA study. AIDS. 2001, 15: 983-990. 10.1097/00002030-200105250-00006.
Article
CAS
PubMed
Google Scholar
Hogg RS, Yip B, Chan KJ, Wood E, Craib KJ, O'Shaughnessy MV, Montaner JS: Rates of disease progression by baseline CD4 cell count and viral load after initiating triple-drug therapy. JAMA. 2001, 286: 2568-2577. 10.1001/jama.286.20.2568.
Article
CAS
PubMed
Google Scholar
US Department of Health and Human Services: Guidelines for the Use of Antiretroviral Agents in HIV-1–Infected Adults and Adolescents. 2004
Google Scholar
Hamilton JD, Hartigan PM, Simberkoff MS, Day PL, Diamond GR, Dickinson GM, Drusano GL, Egorin MJ, George WL, Gordin FM, Hawkes CA, Jensen PC, Klimas NG, Labriola AM, Lahart CJ, O’Brien WA, Oster CN, Weinhold KJ, Wray NP, Zolla-Pazna SB, Veterans Affairs Cooperative Study Group on AIDA Treatment: A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. Results of the veterans’ affairs cooperative study. N Engl J Med. 1992, 326: 437-443. 10.1056/NEJM199202133260703.
Article
CAS
PubMed
Google Scholar
Yeni PG, Hammer SM, Hirsch MS, Saag MS, Schechter M, Carpenter CC, Fischl MA, Gatell JM, Gazzard BG, Jacobsen DM, Katzenstein DA, Montaner JS, Richman DD, Schooley RT, Thompson MA, Vella S, Volberding PA: Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society - USA Panel. JAMA. 2004, 292: 251-265. 10.1001/jama.292.2.251.
Article
CAS
PubMed
Google Scholar
Thompson MA, Aberg JA, Hoy JF, Telenti A, Benson C, Cahn P, Eron JJ, Gunthard HF, Hammer SH, Reiss P, Richman DD, Rizzardini G, Thomas DL, Jacobsen DM, Volberding PA: Antiretroviral treatment of adult HIV Infection: 2012 recommendations of the international antiviral society–USA panel. JAMA. 2012, 308: 387-402. 10.1001/jama.2012.7961.
CAS
PubMed
Google Scholar
Lundgren JD, Babiker AG, Gordin FM, Borges ÁH, Neaton JD: When to start antiretroviral therapy: the need for an evidence base during early HIV infection. BMC Med. 2013, 11: 148.
Article
PubMed
PubMed Central
Google Scholar
Kappes JC, Saag MS, Shaw GM, Hahn BH, Chopra P, Chen S, Emini EA, McFarland R, Yang LC, Piatak M, et al: Assessment of antiretroviral therapy by plasma viral load testing: standard and ICD HIV-1 p24 antigen and viral RNA (QC-PCR) assays compared. Acquir Immune Defic Syndrom Hum Retrovir. 1995, 10: 139-149. 10.1097/00042560-199510020-00005.
Article
CAS
Google Scholar
Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM: Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 1995, 373: 12.
Article
Google Scholar
Emini EA, Graham DJ, Gotlib L: HIV and multidrug resistance. Nature. 1993, 364: 679.
Article
CAS
PubMed
Google Scholar
Deeks SG: HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011, 62: 141-155. 10.1146/annurev-med-042909-093756.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hunt PW, Martin JN, Sinclair E, Bredt B, Hagos E, Lampiris H, Deeks SG: T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus–infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003, 187: 1534-1543. 10.1086/374786.
Article
CAS
PubMed
Google Scholar
Jain V, Hartogensis W, Bacchetti P, Hunt P, Epling L, Sinclair E, Lee TH, Busch M, Hecht F, Deeks S: ART initiation during acute/early HIV infection compared to later ART initiation is associated with improved immunologic and virologic parameters during suppressive ART. Abstracts of the 18th Conference on Retroviruses and Opportunistic Infections, February 27 to March 2, 2011. 2011, Boston, MA: Congress on Retroviruses and Opportunistic Infections, Abstract #517
Google Scholar
Boulware DR, Hullsiek KH, Puronen CE, Rupert A, Baker JV, French MA, Bohjanen PR, Novak RM, Neaton JD, Sereti I, INSIGHT Study Group: Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death. J Infect Dis. 2011, 203: 1637-1646. 10.1093/infdis/jir134.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tien PC, Choi AI, Zolopa AR, Benson C, Tracy R, Scherzer R, Bacchetti P, Shlipak M, Grunfeld C: Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohort. J Acquir Immune Defic Syndr. 2010, 55: 316-322. 10.1097/QAI.0b013e3181e66216.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hunt P, Rodriguez B, Shive C, Clagett B, Funderburg N, van Natta M, Medvik K, Huang Y, Meinert C, Lederman M: Gut epithelial barrier dysfunction, inflammation, and coagulation predict higher mortality during treated HIV/AIDS. Abstracts of the 19th Conference of Retroviruses and Opportunistic Infections. Congress on Retroviruses and Opportunistic Infections, 5-8 March 2012. 2012, Seattle, WA, Abstract #278
Google Scholar
Hunt PW, Cao HL, Muzoora C, Ssewanyana I, Bennett J, Emenyonu N, Kembabazi A, Neilands TB, Bangsberg DR, Deeks SG, Martin JN: Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy. AIDS. 2011, 25: 2123-2131. 10.1097/QAD.0b013e32834c4ac1.
Article
CAS
PubMed
PubMed Central
Google Scholar
Justice AC, Freiberg MS, Tracy R, Kuller L, Tate JP, Goetz MB, Fiellin DA, Vanasse GJ, Butt AA, Rodriguez-Barradas MC, Gibert C, Oursler KA, Deeks SG, Bryant K, VACS Project Team: Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV?. Clin Infect Dis. 2012, 54: 984-994. 10.1093/cid/cir989.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schouten J, Wit FW, Stolte IG, van der Valk M, Geerlings SE, de Wolf F, Prins M, Reiss P, on behalf of the AGEhIV Cohort Study Group: Comorbidity and ageing in HIV-1 infection: the AGEhIV Cohort Study. XIX International AIDS Conference, 22-27 July 2012. 2012, Washington, DC, USA: JAIDS, Oral Abstract
Google Scholar
Althoff K, Wyatt C, Gilbert C, Oursler KA, Rimland D, Rodriguez-Barradas M, McGinnis K, Skanderson M, Gebo K, Justice AC for the Veterans Aging Cohort Study (VACS): HIV + adults are at greater risk for myocardial infarction, non-AIDS cancer, and end-stage renal disease, but events occur at similar ages compared to HIV– adults. 20th Conference on Retroviruses and Opportunistic Infections, 3-6 March 2013. 2013, Atlanta, GA, USA: Congress on Retroviruses and Opportunistic Infections 2013
Google Scholar
van Sighem A, Kesselring A, Gras L, Prins J, Hassink E, Kauffmann R, Richter C, Reiss P, de Wolf F: ATHENA National Observational Cohort: Risk of non-AIDS-defining events amongst HIV + patients not yet on ART. 20th Conference on Retroviruses and Opportunistic Infections, 3-6. 2013, Atlanta, GA, USA: Congress on Retroviruses and Opportunistic Infections; 2013, Abstract 1042, March.
Google Scholar
Couzin-Frankel J: Inflammation bares a dark side. Science. 2010, 1: 1621.
Article
Google Scholar
Hall AM, Hendry BM, Nitsch D, Connolly JO: Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence. Nat Rev. 2011, 57: 773-780.
CAS
Google Scholar
Mayer KH, Valerianna A, Tebas P: Bone disease and HIV infection. Clin Infect Dis. 2006, 42: 108-114. 10.1086/498511.
Article
Google Scholar
Pao V, Lee GA, Grunfeld C: HIV therapy, metabolic syndrome, and cardiovascular risk. Curr Atheroscler Rep. 2008, 10: 61-70. 10.1007/s11883-008-0010-6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Friis-Møller N, Reiss P, Sabin CA, Weber R, Monforte A, El-Sadr W, Thiébaut R, de Wit S, Kirk O, Fontas E, Law MG, Phillips A, Lundgren JD, DAD Study Group: Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med. 2007, 356: 1723-1735.
Article
PubMed
Google Scholar
Squires K, Lazzarin A, Gatell J, Powderly WG, Pokrovskiy V, Delfraissy JF, Jemsek J, Rivero A, Rozenbaum W, Schrader S, Sension M, Vibhagool A, Thiry A, Giordano M: Comparison of once-daily atazanavir with efavirenz, each in combination with fixed dosed zidovudine and lamivudine, as initial therapy for HIV infection. J Acquir Immune Defic Syndr. 2004, 36: 1011-1019. 10.1097/00126334-200408150-00003.
Article
CAS
PubMed
Google Scholar
Gathe JC, Ive P, Wood R, Schürmann D, Bellos NC, DeJesus E, Gladysz A, Garris C, Yeo J: SOLO: 48-week efficacy and safety comparison of once daily fosamprenavir/ritonavir versus twice daily nelfinavir in naive HIV-1-infected patients. AIDS. 2004, 18: 1529-1537. 10.1097/01.aids.0000131332.30548.92.
Article
CAS
PubMed
Google Scholar
Gallant J, Staszewski S, Pozniak A, DeJesus E, Suleiman JM, Miller MD, Coakley DF, Lu B, Toole JJ, Cheng AK, 903 Study Group: Efficacy and safety of tenofovir DF vs. stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial. JAMA. 2004, 292: 191-201. 10.1001/jama.292.2.191.
Article
CAS
PubMed
Google Scholar
McKinnell JA, Willig JH, Westfall AO, Nevin C, Allison JJ, Raper JL, Mugavero MJ, Saag MS: Antiretroviral prescribing patterns in treatment-naive patients in the united states. AIDS Patient Care STDS. 2010, 24: 2.
Article
Google Scholar
Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, Hogg RS, Deeks SG, Eron JJ, Brooks JT, Rourke SB, Gill MJ, Bosch RJ, Martin JN, Klein MB, Jacobson LP, Rodriguez B, Sterling TR, Kirk GD, Napravnik S, Rachlis AR, Calzavara LM, Horberg MA, Silverberg MJ, Gebo KA, Goedert JJ, Benson CA, Collier AC, van Rompaey SE, Crane HM, et al: Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med. 2009, 360: 1815-1826. 10.1056/NEJMoa0807252.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, Harris R, Funk MJ, Geskus RB, Gill J, Dabis F, Miró JM, Justice AC, Ledergerber B, Fätkenheuer G, Hogg RS, Monforte AD, Saag M, Smith C, Staszewski S, Egger M, Cole SR, When To Start Consortium: Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009, 373: 1352-1363.
Article
PubMed
Google Scholar
Writing Committee for the CASCADE Collaboration: Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters. Arch Intern Med. 2011, 171: 1560-1569. 10.1001/archinternmed.2011.401.
Article
Google Scholar
Hogan CM, Degruttola V, Sun X, Fiscus SA, del Rio C, Hare CB, Markowitz M, Connick E, Macatangay B, Tashima KT, Kallungal B, Camp R, Morton T, Daar ES, Little S, A5217 Study Team: The setpoint study (ACTG A5217): effect of immediate versus deferred antiretroviral therapy on virologic set point in recently HIV-1-infected individuals. J Infect Dis. 2012, 205: 87-96. 10.1093/infdis/jir699.
Article
CAS
PubMed
Google Scholar
Moore RD, Keruly JC: CD4 cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. Clin Infect Dis. 2007, 44: 441-446. 10.1086/510746.
Article
PubMed
Google Scholar
Geng EH, Hare CB, Kahn JO, Jain V, van Nunnery T, Christopoulos KA, Deeks SG, Gandhi M, Havlir DV: The effect of a “universal antiretroviral therapy” recommendation on HIV RNA levels among HIV-infected patients entering care with a CD4 count greater than 500/muL in a public health setting. Clin Infect Dis. 2012, 55: 1690-1697. 10.1093/cid/cis750.
Article
CAS
PubMed
PubMed Central
Google Scholar
Uy J, Armon C, Buchacz K, Wood K, Brooks JT, HOPS Investigators: Initiation of HAART at higher CD4 cell counts is associated with a lower frequency of antiretroviral drug resistance mutations at virologic failure. J Acquir Immune Defic Syndr. 2009, 51: 450-453. 10.1097/QAI.0b013e3181acb630.
Article
PubMed
Google Scholar
Mauskopf J, Kitahata M, Kauf T, Richter A, Tolson J: HIV antiretroviral treatment: early versus later. Acquir Immune Defic Syndr. 2005, 39: 562-569.
CAS
Google Scholar
de Cock KM, El-Sadr WM: When to start ART in Africa–an urgent research priority. N Engl J Med. 2013, 368: 886-889. 10.1056/NEJMp1300458.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole SV, Mehendale S, Chariyalertsak S, Santos BR, Mayer KH, Hoffman IF, Eshleman SH, Piwowar-Manning E, Wang L, Makhema J, Mills LA, de Bruyn G, Sanne I, Eron J, Gallant J, Havlir D, Swindells S, Ribaudo H, Elharrar V, Burns D, et al: Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011, 365: 493-505. 10.1056/NEJMoa1105243.
Article
CAS
PubMed
PubMed Central
Google Scholar
Granich RM, Gilks CF, Dye C, de Cock KM, Williams BG: Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009, 373: 48-57. 10.1016/S0140-6736(08)61697-9.
Article
PubMed
Google Scholar
Reynolds S, Makumbi F, Kagaayi J, Nakigozi G, Galiwongo R, Quinn T, Wawer M, Gray R, Serwadda D: ART reduced the rate of sexual transmission of HIV among HIV-discordant couples in rural Rakai, Uganda. Paper presented at: 16th Conference on Retroviruses and Opportunistic Infections, 8-11 February 2009. 2009, Montreal, QC, Canada
Google Scholar
Sullivan P, Kayitenkore K, Chomba E, Karita E, Mwananyanda L, Vwalika C, Conkling M, Luisi N, Tichacek A, Allen S: Reduction of HIV transmission risk and high risk sex while prescribed ART: results from discordant couples in Rwanda and Zambia. Paper presented at: 16th Conference on Retroviruses and Opportunistic Infections, 8-11 February 2009. 2009, Montreal, QC, Canada
Google Scholar
Bunnell R, Ekwaru JP, Solberg P, Wamai N, Bikaako-Kajura W, Were W, Coutinho A, Liechty C, Madraa E, Rutherford G, Mermin J: Changes in sexual behavior and risk of HIV transmission after antiretroviral therapy and prevention interventions in rural Uganda. AIDS. 2006, 20: 85-92. 10.1097/01.aids.0000196566.40702.28.
Article
PubMed
Google Scholar
Castilla J, del Romero J, Hernando V, Marincovich B, Garcia S, Rodriguez C: Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV. J Acquir Immune Defic Syndr. 2005, 40: 96-101. 10.1097/01.qai.0000157389.78374.45.
Article
PubMed
Google Scholar
Wilson DP, Law MG, Grulich AE, Cooper DA, Kaldor JM: Relation between HIV viral load and infectiousness: a model-based analysis. Lancet. 2008, 372: 314-320. 10.1016/S0140-6736(08)61115-0.
Article
PubMed
Google Scholar
Marks G, Crepaz N, Janssen RS: Estimating sexual transmission of HIV from persons aware and unaware that they are infected with the virus in the USA. AIDS. 2006, 20: 1447-1450. 10.1097/01.aids.0000233579.79714.8d.
Article
PubMed
Google Scholar
NIAID HIV and Emerging Infectious Diseases Program: Strategic timing of anti-retroviral treatment (start trial). Available at: http://www.niaid.nih.gov/volunteer/hivandinfectious/hivstudies/Pages/STARTStudy.aspx