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Table 3 Similarities in immunoinflammatory pathways between encephalomyelitis disseminata/multiple sclerosis (ED/MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Immunoinflammatory pathways



Raised levels of proinflammatory cytokines, for example, interleukin (IL) 1 and tumor necrosis factor-α

Increased nuclear factor κB

Increased cyclo-oxygenase 2

Raised IL-2

Raised IL-10

Raised transforming growth factor β

Coexistence of a T helper (Th)1 and Th2 response

Elevated osteopontin levels

Temporal variation in cytokine profile

Elevated neopterin

T regulatory (Treg) dysfunction

Forkhead box P3 (FOXP3) dysfunction

Clonal exhaustion of T cells

Elevated CD26

CD69 expression

Low natural killer cell activity

Chronic activation of immunoinflammatory pathways