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Table 5 Similarities in mitochondral and brain dysfunctions between encephalomyelitis disseminata/multiple sclerosis (ED/MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Mitochondrial dysfunctions ED/MS ME/CFS
Depleted ATP production (muscle and brain)
Decreased phosphocreatine resynthesis following exercise
Impaired oxidative phosphorylation
Acceleration of glycolysis ?
Damage to mitochondrial respiratory chain in neurons ?
Oxidative mitochondrial damage
Mitochondrial energy failure
Brain dysfunctions:   
Cerebral hypoperfusion
Reduced cerebral glucose metabolism
Gray matter atrophy
Increased cerebral lactate
Increased cerebral choline
Reduced levels of N-acetyl aspartate