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Table 5 Similarities in mitochondral and brain dysfunctions between encephalomyelitis disseminata/multiple sclerosis (ED/MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Mitochondrial dysfunctions

ED/MS

ME/CFS

Depleted ATP production (muscle and brain)

Decreased phosphocreatine resynthesis following exercise

Impaired oxidative phosphorylation

Acceleration of glycolysis

?

Damage to mitochondrial respiratory chain in neurons

?

Oxidative mitochondrial damage

Mitochondrial energy failure

Brain dysfunctions:

  

Cerebral hypoperfusion

Reduced cerebral glucose metabolism

Gray matter atrophy

Increased cerebral lactate

Increased cerebral choline

Reduced levels of N-acetyl aspartate