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Table 5 Similarities in mitochondral and brain dysfunctions between encephalomyelitis disseminata/multiple sclerosis (ED/MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

From: Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

Mitochondrial dysfunctions



Depleted ATP production (muscle and brain)

Decreased phosphocreatine resynthesis following exercise

Impaired oxidative phosphorylation

Acceleration of glycolysis


Damage to mitochondrial respiratory chain in neurons


Oxidative mitochondrial damage

Mitochondrial energy failure

Brain dysfunctions:


Cerebral hypoperfusion

Reduced cerebral glucose metabolism

Gray matter atrophy

Increased cerebral lactate

Increased cerebral choline

Reduced levels of N-acetyl aspartate