Hermanns-Sachweh B, Senderek J, Alfer J, Klosterhalfen B, Buttner R, Fuzesi L, Weber M: Vascular changes in the periosteum of congenital pseudarthrosis of the tibia. Pathol Res Pract. 2005, 201 (4): 305-312. 10.1016/j.prp.2004.09.013.
Article
PubMed
Google Scholar
Stevenson DA, Birch PH, Friedman JM, Viskochil DH, Balestrazzi P, Boni S, Buske A, Korf BR, Niimura M, Pivnick EK, Schorry EK, Short MP, Tenconi R, Tonsgard JH, Carey JC: Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1. Am J Med Genet. 1999, 84 (5): 413-419. 10.1002/(SICI)1096-8628(19990611)84:5<413::AID-AJMG5>3.0.CO;2-1.
Article
CAS
PubMed
Google Scholar
Stevenson DA, Zhou H, Ashrafi S, Messiaen LM, Carey JC, D'Astous JL, Santora SD, Viskochil DH: Double inactivation of NF1 in tibial pseudarthrosis. Am J Hum Genet. 2006, 79 (1): 143-148. 10.1086/504441.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kolanczyk M, Kossler N, Kuhnisch J, Lavitas L, Stricker S, Wilkening U, Manjubala I, Fratzl P, Sporle R, Herrmann BG, Parada LF, Kornak U, Mundlos S: Multiple roles for neurofibromin in skeletal development and growth. Hum Mol Genet. 2007, 16 (8): 874-886. 10.1093/hmg/ddm032.
Article
CAS
PubMed
Google Scholar
Campbell TM, Wong WT, Mackie EJ: Establishment of a model of cortical bone repair in mice. Calcif Tissue Int. 2003, 73 (1): 49-55. 10.1007/s00223-002-2120-4.
Article
CAS
PubMed
Google Scholar
Song SJ, Pagel CN, Campbell TM, Pike RN, Mackie EJ: The role of protease-activated receptor-1 in bone healing. Am J Pathol. 2005, 166 (3): 857-868.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sakamoto A, Yoshida T, Yamamoto H, Oda Y, Tsuneyoshi M, Iwamoto Y: Congenital pseudarthrosis of the tibia: analysis of the histology and the NF1 gene. J Orthop Sci. 2007, 12 (4): 361-365. 10.1007/s00776-007-1142-1.
Article
CAS
PubMed
Google Scholar
Kuorilehto T, Kinnunen P, Nissinen M, Alanne M, Leskela HV, Lehenkari P, Peltonen J: Vasculopathy in two cases of NF1-related congenital pseudarthrosis. Pathol Res Pract. 2006, 202 (9): 687-690. 10.1016/j.prp.2006.03.006.
Article
PubMed
Google Scholar
Khanzada UK, Pardo OE, Meier C, Downward J, Seckl MJ, Arcaro A: Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling. Oncogene. 2006, 25 (6): 877-887. 10.1038/sj.onc.1209117.
Article
CAS
PubMed
Google Scholar
Morgan MA, Sebil T, Aydilek E, Peest D, Ganser A, Reuter CW: Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol. 2005, 130 (6): 912-925. 10.1111/j.1365-2141.2005.05696.x.
Article
CAS
PubMed
Google Scholar
Ghittoni R, Patrussi L, Pirozzi K, Pellegrini M, Lazzerini PE, Capecchi PL, Pasini FL, Baldari CT: Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. Faseb J. 2005, 19 (6): 605-607.
CAS
PubMed
Google Scholar
Garrett IR, Gutierrez GE, Rossini G, Nyman J, McCluskey B, Flores A, Mundy GR: Locally delivered lovastatin nanoparticles enhance fracture healing in rats. J Orthop Res. 2007, 25 (10): 1351-1357. 10.1002/jor.20391.
Article
CAS
PubMed
Google Scholar
Skoglund B, Aspenberg P: Locally applied Simvastatin improves fracture healing in mice. BMC Musculoskelet Disord. 2007, 8: 98-10.1186/1471-2474-8-98.
Article
PubMed
PubMed Central
Google Scholar
Skoglund B, Forslund C, Aspenberg P: Simvastatin improves fracture healing in mice. J Bone Miner Res. 2002, 17 (11): 2004-2008. 10.1359/jbmr.2002.17.11.2004.
Article
CAS
PubMed
Google Scholar
Ohnaka K, Shimoda S, Nawata H, Shimokawa H, Kaibuchi K, Iwamoto Y, Takayanagi R: Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun. 2001, 287 (2): 337-342. 10.1006/bbrc.2001.5597.
Article
CAS
PubMed
Google Scholar
Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA, Reszka AA: Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci USA. 1999, 96 (1): 133-138. 10.1073/pnas.96.1.133.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jadhav SB, Jain GK: Statins and osteoporosis: new role for old drugs. J Pharm Pharmacol. 2006, 58 (1): 3-18. 10.1211/jpp.58.1.0002.
Article
CAS
PubMed
Google Scholar
Li W, Cui Y, Kushner SA, Brown RA, Jentsch JD, Frankland PW, Cannon TD, Silva AJ: The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol. 2005, 15 (21): 1961-1967. 10.1016/j.cub.2005.09.043.
Article
CAS
PubMed
Google Scholar
Zhu Y, Romero MI, Ghosh P, Ye Z, Charnay P, Rushing EJ, Marth JD, Parada LF: Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001, 15 (7): 859-876. 10.1101/gad.862101.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kita T, Brown MS, Goldstein JL: Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. J Clin Invest. 1980, 66 (5): 1094-1100. 10.1172/JCI109938.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ratzka A, Kalus I, Moser M, Dierks T, Mundlos S, Vortkamp A: Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev Dyn. 2008, 237 (2): 339-353. 10.1002/dvdy.21423.
Article
CAS
PubMed
Google Scholar
Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ: Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science. 1996, 273 (5275): 613-622. 10.1126/science.273.5275.613.
Article
CAS
PubMed
Google Scholar
Yoshitake H, Rittling SR, Denhardt DT, Noda M: Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci USA. 1999, 96 (14): 8156-8160. 10.1073/pnas.96.14.8156.
Article
CAS
PubMed
PubMed Central
Google Scholar
Asou Y, Rittling SR, Yoshitake H, Tsuji K, Shinomiya K, Nifuji A, Denhardt DT, Noda M: Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone. Endocrinology. 2001, 142 (3): 1325-1332. 10.1210/en.142.3.1325.
CAS
PubMed
Google Scholar
Yu X, Chen S, Potter OL, Murthy SM, Li J, Pulcini JM, Ohashi N, Winata T, Everett ET, Ingram D, Clapp WD, Hock JM: Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning. Bone. 2005, 36 (5): 793-802. 10.1016/j.bone.2005.01.022.
Article
CAS
PubMed
Google Scholar
Konishi K, Nakamura M, Yamakawa H, Suzuki H, Saruta T, Hanaoka H, Davatchi F: Hypophosphatemic osteomalacia in von Recklinghausen neurofibromatosis. Am J Med Sci. 1991, 301 (5): 322-328. 10.1097/00000441-199105000-00006.
Article
CAS
PubMed
Google Scholar
Weinstein RS, Harris RL: Hypercalcemic hyperparathyroidism and hypophosphatemic osteomalacia complicating neurofibromatosis. Calcif Tissue Int. 1990, 46 (6): 361-366. 10.1007/BF02554965.
Article
CAS
PubMed
Google Scholar
Kuorilehto T, Poyhonen M, Bloigu R, Heikkinen J, Vaananen K, Peltonen J: Decreased bone mineral density and content in neurofibromatosis type 1: lowest local values are located in the load-carrying parts of the body. Osteoporos Int. 2005, 16 (8): 928-936. 10.1007/s00198-004-1801-4.
Article
CAS
PubMed
Google Scholar
Ben-Baruch D, Ziv Y, Sandbank J, Wolloch Y: Oncogenic osteomalacia induced by schwannoma in a patient with neurofibromatosis. Eur J Surg Oncol. 1994, 20 (1): 57-61.
CAS
PubMed
Google Scholar
Mundy GR: Directions of drug discovery in osteoporosis. Annu Rev Med. 2002, 53: 337-354. 10.1146/annurev.med.53.082901.104047.
Article
CAS
PubMed
Google Scholar
Khosravi-Far R, Cox AD, Kato K, Der CJ: Protein prenylation: key to ras function and cancer intervention?. Cell Growth Differ. 1992, 3 (7): 461-469.
CAS
PubMed
Google Scholar
Elefteriou F, Benson MD, Sowa H, Starbuck M, Liu X, Ron D, Parada LF, Karsenty G: ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab. 2006, 4 (6): 441-451. 10.1016/j.cmet.2006.10.010.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kono SJ, Oshima Y, Hoshi K, Bonewald LF, Oda H, Nakamura K, Kawaguchi H, Tanaka S: Erk pathways negatively regulate matrix mineralization. Bone. 2007, 40 (1): 68-74. 10.1016/j.bone.2006.07.024.
Article
CAS
PubMed
Google Scholar