Figure 2
From: Zinc Finger Nucleases as tools to understand and treat human diseases
Functional domains attached to zinc finger proteins. This figure presents a summary of the functional domains that have been demonstrated to be targeted to specific DNA regions by zinc finger proteins. Shown are the structures of the VP16 transactivation domain from the complex with PC4 (2PHE), the Kruppel associated box domain (1V65), the histone H3K9 methyl transferase Suv39H1 (2R3A), HhaI DNA methyl transferase (1MHT) and FokI endonuclease (1FOK).