World Health Organization: Global Health Risks: Mortality and Burden of Disease Attributable to Selected Major Risk Factors. 2009, Geneva, Switzerland: World Health Organization
Google Scholar
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002, 346: 393-403. 10.1056/NEJMoa012512.
Article
CAS
PubMed
Google Scholar
Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Aunola S, Cepaitis Z, Moltchanov V, Hakumaki M, Mannelin M, Martikkala V, Sundvall J, Uusitupa M, Finnish Diabetes Prevention Study Group: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001, 344: 1343-1350. 10.1056/NEJM200105033441801.
Article
CAS
PubMed
Google Scholar
Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006, 295: 1549-1555. 10.1001/jama.295.13.1549.
Article
CAS
PubMed
Google Scholar
Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, Nielsen AL, Albrechtsen A, Borch-Johnsen K, Rasmussen SS, Clausen JO, Sandbaek A, Lauritzen T, Hansen L, Jorgensen T, Pedersen O, Hansen T: Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes. 2008, 57: 95-101. 10.2337/db07-0910.
Article
CAS
PubMed
Google Scholar
Franks PW, Loos RJ: PGC-1alpha gene and physical activity in type 2 diabetes mellitus. Exerc Sport Sci Rev. 2006, 34: 171-175. 10.1249/01.jes.0000240021.92254.23.
Article
PubMed
Google Scholar
Bird A: Perceptions of epigenetics. Nature. 2007, 447: 396-398. 10.1038/nature05913.
Article
CAS
PubMed
Google Scholar
McGee SL, Hargreaves M: Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle. Diabetes. 2004, 53: 1208-1214. 10.2337/diabetes.53.5.1208.
Article
CAS
PubMed
Google Scholar
McGee SL, Hargreaves M: Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms. Clin Exp Pharmacol Physiol. 2006, 33: 395-399. 10.1111/j.1440-1681.2006.04362.x.
Article
CAS
PubMed
Google Scholar
McGee SL, Howlett KF, Starkie RL, Cameron-Smith D, Kemp BE, Hargreaves M: Exercise increases nuclear AMPK α2 in human skeletal muscle. Diabetes. 2003, 52: 926-928. 10.2337/diabetes.52.4.926.
Article
CAS
PubMed
Google Scholar
McGee SL, Sparling D, Olson AL, Hargreaves M: Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle. FASEB J. 2006, 20: 348-349.
CAS
PubMed
Google Scholar
McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE, Hargreaves M: AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes. 2008, 57: 860-867. 10.2337/db07-0843.
Article
CAS
PubMed
Google Scholar
Brøns C, Jacobsen S, Nilsson E, Rönn T, Jensen CB, Storgaard H, Poulsen P, Groop L, Ling C, Astrup A, Vaag A: Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. J Clin Endocrinol Metab. 2010, 95: 3048-3056.
Article
PubMed
Google Scholar
Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC: Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005, 135: 1382-1386.
CAS
PubMed
Google Scholar
Lillycrop KA, Phillips ES, Torrens C, Hanson MA, Jackson AA, Burdge GC: Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring. Br J Nutr. 2008, 100: 278-282. 10.1017/S0007114507894438.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lillycrop KA, Slater-Jefferies JL, Hanson MA, Godfrey KM, Jackson AA, Burdge GC: Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr. 2007, 97: 1064-1073. 10.1017/S000711450769196X.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bouchard L, Rabasa-Lhoret R, Faraj M, Lavoie ME, Mill J, Pérusse L, Vohl MC: Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction. Am J Clin Nutr. 2010, 91: 309-320. 10.3945/ajcn.2009.28085.
Article
CAS
PubMed
Google Scholar
Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M: Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA. 2005, 102: 10604-10609. 10.1073/pnas.0500398102.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ling C, Groop L: Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes. 2009, 58: 2718-2725. 10.2337/db09-1003.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ling C, Del Guerra S, Lupi R, Rönn T, Granhall C, Luthman H, Masiello P, Marchetti P, Groop L, Del Prato S: Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia. 2008, 51 (4): 615-22. 10.1007/s00125-007-0916-5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ronn T, Poulsen P, Hansson O, Holmkvist J, Almgren P, Nilsson P, Tuomi T, Isomaa B, Groop L, Vaag A, Ling C: Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia. 2008, 51: 1159-1168. 10.1007/s00125-008-1018-8.
Article
CAS
PubMed
Google Scholar
Ling C, Poulsen P, Simonsson S, Ronn T, Holmkvist J, Almgren P, Hagert P, Nilsson E, Mabey AG, Nilsson P, Vaag A, Groop L: Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest. 2007, 117: 3427-3435. 10.1172/JCI30938.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR: Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009, 462: 315-322. 10.1038/nature08514.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tobi EW, Lumey LH, Talens RP, Kremer D, Putter H, Stein AD, Slagboom PE, Heijmans BT: DNA Methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet. 2009, 18: 4046-4053. 10.1093/hmg/ddp353.
Article
CAS
PubMed
PubMed Central
Google Scholar
Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, Slagboom PE, Lumey LH: Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci USA. 2008, 105: 17046-17049. 10.1073/pnas.0806560105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang X, Zhu H, Sneider H, Su S, Munn D, Harshfiels G, Maria BL, Dong Y, Treiber F, Gutin B, Shi H: Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Med. 2010, 8: 87-10.1186/1741-7015-8-14.
Article
PubMed
PubMed Central
Google Scholar
Carpino N, Turner S, Mekala D, Takahashi Y, Zang H, Geiger TL, Doherty P, Ihle JN: Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity. 2004, 20: 37-46. 10.1016/S1074-7613(03)00351-0.
Article
CAS
PubMed
Google Scholar
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS: Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009, 41: 703-707. 10.1038/ng.381.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ozato K, Shin DM, Chang TH, Morse HC: TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol. 2008, 8: 849-860. 10.1038/nri2413.
Article
CAS
PubMed
PubMed Central
Google Scholar
Plagemann A, Harder T, Brunn M, Harder A, Roepke K, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K, Dudenhausen JW: Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol. 2009, 587: 4963-4976. 10.1113/jphysiol.2009.176156.
Article
CAS
PubMed
PubMed Central
Google Scholar